Simultaneous Determination of the Novel Neuroprotective Agent KR-31378 and its Metabolite KR-31612 Using High Performance Liquid Chromatography with Tandem Mass Spectrometry in Human Plasma
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Kim, John
(Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Department of Clinical Research, LG Life Sciences, Ltd)
Ji, Hye-Young (Medicinal Resources Research Center and Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University) Yoo, Sung-Eun (Korea Research Institute of Chemical Technology) Kim, Sun-Ok (AgroPharma Research Institute, Dongbu Hannong Chemical Company) Lee, Dong-Ha (Department of Clinical Research, LG Life Sciences, Ltd.) Lim, Hong (Department of Clinical Research, LG Life Sciences, Ltd.) Lee, Hye-Suk (Medicinal Resources Research Center and Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University) |
1 | Kim, H. J., Kim,S. H., Kim,S.-O.,Lee, D.-H., Lim, H., Yoo, S. E. and Lee, M. G., Dose-dependent pharmacokinetics of a new neuroprotective agent for ischemia-reperfusion damage, KR31378, in rats. Biopharm. Drug Dispos., 21, 279-284 (2000) DOI ScienceOn |
2 | Yoo, S. E, Yi, K. Y, Lee, S., Suh, J., Kim, N., Lee, B. H., Sea, H. W., Kim, S. O., Lee, D. H., Lim, H. and Shin, H. S., A novel anti-ischemic ATP-sensitive potassium channel opener without vasorelaxation: N-(6-aminobenzopyranyl)-N'-benzylN"-cyanoguanidine analogue. J. Med. Chem., 44, 4207-4215 (2001) DOI ScienceOn |
3 | Lee, M.H., Kim, H. J., Kim, S. H., Kim, S.-O., Lee, D.-H., Lim, H., Yoo, S. E. and Lee, M. G., High-performance liquid chromatographic analysis of a new neuropratective agent far ischemia-reperfusion damage, KR-31378. Res. Com. Mol. Pathol. Pharmacol., in press. |
4 | Hong, K.W., Kim, K. Y., Lee, J. H., Shin, H. K., Kwak,Y. G., Kim, S. O., Lim, H. and Yoo, S. E., Neuroprotective effect of (2S,3S,4R)-N"-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378), a benzopyran analog, against focal ischemic brain damage in rats. J. Pharmacol. Exp. Ther., 301, 210-216 (2002) DOI ScienceOn |
5 | Kim, K. Y, Kim, B. G., Kim, S. O., Yoo, S. E., Kwak, Y G.., Chae, S.W and Hong, K. W., Prevention of lipopolysaccharide-induced apoptosis by (2S,3S,4R)-N"-cyano-N-(6-amino-3,4dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine, a benzopyran analog, in endothelial cells. J. Pharmacal. Exp. Ther., 300, 535-542 (2002) DOI ScienceOn |
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