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Phytochemical Constituens of Cirsium setidens Nakai and Their Cytotoxicity against Human Cancer Cell Lines  

Lee, Won-Bin (College of Pharmacy, SungKyunKwan University)
Kwon, Hak-Cheol (College of Pharmacy, SungKyunKwan University)
Chol, Ock-Ryun (College of Pharmacy, SungKyunKwan University)
Lee, Kang-Choon (College of Pharmacy, SungKyunKwan University)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Baek, Nam-In (Graduate School of Biotechnology ＆ Plant Metabolism Research Center, Kyunghee University)
Lee, Kang-Ro (College of Pharmacy, SungKyunKwan University)
Publication Information
Archives of Pharmacal Research / v.25, no.5, 2002 , pp. 628-635 More about this Journal
Abstract
Five terpenes (1~5), three fatty acids (6~8), two sterols (9 and 11), and a monogalactosyldiacyl glycerol (10) were isolated from the methylene chloride extract of the aerial part of Cirsium setidens. Their chemical structures were determined to be $\alpha$-tocopherol (1), 25-hydroperoxycycloart-23-en-3$\beta$-o1 (2), 24-hydroperoxycycloart-25-en-3$\beta$-o1 (3), mokko lactone (4), transphytol (5), 9, 12, 15-octadecatrienoic acid (6), 9, 12-octadecadienoic acid (7), hexadecanoic acid (8), acylglycosyl $\beta$-sitosterol (9), (2R)-1, 2-O-(9z, 12z, 15z-dioctadecatrienoyl)-3-O-$\beta$-D-galactopyranosyl glycerol (10) and $\beta$-sitosterol glucoside (11) by spectral evidences. Compound 3 exhibited significant cytotoxic activity against five human cancer cell lines with its $ED_{50}$ values ranging from 2.66 to 11.25 $\mu$M.
Keywords
Cirsium setidens; Compositae; Triterpene hydroperoxide; Cytotoxicity;
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