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Effect of Crystal Form on in Vivo Topical Anti-Inflammatory Activity of Corticosteroids  

Sohn, Young-Taek (College of Pharmacy, Duksung Womenis University)
Kim, Sun-Young (College of Pharmacy, Duksung Womenis University)
Publication Information
Archives of Pharmacal Research / v.25, no.4, 2002 , pp. 556-559 More about this Journal
Abstract
The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolone were prepared and their topical anti-inflammatory activities were measured using arachidonic acid induced ear edema assay in mice. Two crystal forms of the drugs showed differences in anti-inflammatory activity. Among the drugs examined, Form B of prednicarbate and betamethasone 17-valerate showed significantly more potent anti-inflammatory activities as compared to their Form A.
Keywords
Corticosteroids; Crystal Form; Topical anti-inflammation;
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Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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1 Prausnitz, M. R., Pliquett, U., Langer, R. and Weaver, J. C., Rapid temporal control oftransdermal drug delivery by electroporation. Pharm. Res., 11, 1834-1837 (1994)   DOI   ScienceOn
2 Mesley, R. J., The infra-red spectra of certain steroids and dissolution rate of their tablets. Spectrochim. Acta, 22, 889-917 (1966)   DOI   ScienceOn
3 Idson, B., Vehicle effects in percutaneous absorption. Drug Metab. Rev., 14, 207-222 (1983)   DOI   PUBMED   ScienceOn
4 Kim, H. K., Namgoong, S. Y. and Kim, H. P., Anti-inflammatory activity of flavonoids:Mouse ear edema inhibition. Arch. Pharm. Res., 16, 18-24 (1993)   DOI   ScienceOn
5 De Maury; G., Chauvet; A., Terol, A. and Masse, J., Etude thermoanalytique de quelques steroids IV. Prednisolone etderives. Thermochimica Acta, 97, 127-142 (1986)   DOI   ScienceOn
6 Massimo, F. and Giovanni, P., Corticosteroid dermal delivery with skin-lipid liposomes. J. Controlled ReI., 44, 141-151 (1997)   DOI   ScienceOn
7 Green, P. G., Flanagan, M., Shroot, B. and Guy, R. H., Iontophoretic Drug Delivery. In Walters, K.A. and Hadgraft, J. (Eds.). Pharmaceutical skin penetration enhancement, Marcel Decker, New York, pp.331, (1993)
8 Watson, W. S. and Finlay, A. Y., The effect of the vehicle formulation on the stratum corneum penetration characteristics of clobetasoI 17-propionate. Br. J. Dermatol., 118, 523-530 (1988)   DOI   ScienceOn
9 Guillory, J. K., Heat of transition of methylprednisolone and sulfathiazole by a differential thermal analysis method. J. Pharm. Sci., 56, 72-76 (1967)   DOI   PUBMED
10 Buyuktimkin, N., Buyuktimkin, S. and Rytting, J. H., Chemical means of transdermal drug permeation enhancement. In Ghosh, T. K., Pfister, W. R. and Yum, S. I. (Eds.).Transdermal and topical drug delivery systems, Interpharm PressInc., Buffalo Grove, Illinois, pp.357, (1997)
11 Bird, J., Kim, H. P. and Lee, H. J., Anti-inflammatory activity of esters of steroid 21-oicacids. Steroids, 47, 35-40 (1986)   DOI   ScienceOn
12 Veiga, M. D., Cadomiga, R., Fonseca, I. and Garcia-Blanco, S., Polymorphism characterization of prednisolone: spectrometric and diffractometric study. II Farmaco Ed. Pr., 42, 93-102 (1987)
13 Murphy, T. M. and Hardgraft, J. A., Physicochemical interpretation of phonoporesis in skin penetration enhancement. In Scott, R. C., Guy, R. H. and Hardgraft, J. (Eds.). Prediction percutaneous penetration: methods, measurements, modeling, IBC Technical Service Ltd., London, pp 333, (1990)
14 Gao, C. K. and Zahng, R. H., Polymorphic forms of certain steroids and dissolution rate of their tablets. Pharm. Ind., 18, 301-306 (1987)