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Inhibition of Angiogenesis by Propolis  

Song, Yun-Seon (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
Park, Eun-Hee (College of Pharmacy, Sookmyung Womens University)
Jung, Kyung-Ja (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
Jin, Changbae (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
Publication Information
Archives of Pharmacal Research / v.25, no.4, 2002 , pp. 500-504 More about this Journal
Abstract
Propolis, obtained from honeybee hives, has been used in Oriental folk medicine as an anti-inflammatory, anti-carcinogenic, and immunomodulatory agent. There is considerable evidence suggesting that angiogenesis and chronic inflammation are codependent. Blockage of angiogenesis results in an anti-inflammatory effect. Ethanol (EEP) and ether extracts of propolis (REP), and caffeic acid phenethyl ester (CAPE), an active component of propolis, were examined for their anti-angiogenic activities using the chick embryo chorioallantoic membrane (CAM), and the calf pulmonary arterial endothelial (CPAE) cell proliferation, assays. The presence of EEP, REP and CAPE inhibited angiogenesis in the CAM assay and the proliferation of CPAE cells. The results suggest that anti-angiogenic activities of EEP, REP and CAPE are also responsible for their anti-inflammatory effect.
Keywords
Propolis; Caffeic acid phenethyl ester; Angiogenesis; Chorioallantoic membrane; Calf pulmonary arterial endothelial cells;
Citations & Related Records

Times Cited By Web Of Science : 14  (Related Records In Web of Science)
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