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Costunolide Induces Differentiation of Human Leukemia HL-60 Cells  

Choi, Jung-Hye (College of Pharmacy, Kyung Hee University)
Seo, Bo-Rim (College of Pharmacy, Kyung Hee University)
Seo, Seong-Hoon (College of Pharmacy, Kyung Hee University)
Lee, Kyung-Tae (College of Pharmacy, Kyung Hee University)
Park, Jae-Hoon (College of Medicine, Kyung Hee University)
Park, Hee-Juhn (Division of Applied Plant Sciences, Sangji University)
Choi, Jong-Won (College of Pharmacy, Kyung-Sung University)
Yoshie-Itoh (Department of Hospital Pharmacy, School of Medicine, Kanazawa University)
Miyamoto, Ken-Ichi (Department of Hospital Pharmacy, School of Medicine, Kanazawa University)
Publication Information
Archives of Pharmacal Research / v.25, no.4, 2002 , pp. 480-484 More about this Journal
Abstract
Costunolide has been reported to be a cytotoxic and chemopreventive agent. This work investigated the mechanism of the anti proliferative effect of costunolide and determined that it induced differentiation of the human leukemia cell line HL-60. Costunolide exhibited a potent antiproliferative activity against HL-60 cells. It was also found to be a potent inducer of differentiation in human leukemia derived HL-60 cells through the examination of differentiation markers, as assessed by the reduction of nitroblue tetrazolium, the increase in esterase activities and phagocytic activity, morphology change and the expression of CD14 and CD66b surface antigens. These results, accompanied by a decline in the expression of c-myc protein, suggest that costunolide induces differentiation of human leukemia cells to granulocytes and monocytes/macrophages lineage.
Keywords
Costunolide; Differentiation; Granulocyte; Monocyte; HL-60 cell;
Citations & Related Records

Times Cited By Web Of Science : 7  (Related Records In Web of Science)
Times Cited By SCOPUS : 10
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