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Anti-Human Immunodeficiency Virus-Type 1 Activity of Constituents from Juglans mandshurica  

Min, Byung-Sun (Immunomodulator Research Laboratory, KRIBB)
Lee, Hyeong-Kyu (Immunomodulator Research Laboratory, KRIBB)
Lee, Sang-Myung (Immunomodulator Research Laboratory, KRIBB)
Kim, Young-Ho (College of Pharmacy, Chungnam National University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Otake, Toru (Osaka Prefectural Institute of Public health, Osaka, Japan)
Nakamura, Norio (Institute of Natural Medicine, Toyama Medical ＆ Pharmaceutical University)
Hattori, Masao (Institute of Natural Medicine, Toyama Medical ＆ Pharmaceutical University)
Publication Information
Archives of Pharmacal Research / v.25, no.4, 2002 , pp. 441-445 More about this Journal
Abstract
Three naphthalene glycosides (1-3), four flavonoids (4-7), and two galloyl glycosides (8-9) were isolated from the stem-bark of Juglans mandshurica (Juglandaceae). Their structures were determined by chemical and spectral means, including to 2D-NMR (COSY, HMQC, and HMBC) experiments. Amongst the isolated compounds, taxifolin (4) showed the most potent HIV-induced cytopethic activity against MT-4 cells with complete inhibitory concentration ($IC_{100}$) value of $25{\;}{\mu\textrm{g}}/ml$ and maximum cytotoxic concentration ($CC_{100}$) value of above $100{\;}{\mu\textrm{g}}/ml$. However, naphthalene glycosides (1-3), flavonoids (5-7)), and galloyl tannins (8-9) were inactive against anti-HIV-1 activity.
Keywords
Juglans mandshurica; Taxifolin; Anti-HIV activity; MT-4 cells;
Citations & Related Records

Times Cited By Web Of Science : 10  (Related Records In Web of Science)
Times Cited By SCOPUS : 13
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