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Recognition of the Importance of Imidazolidinone Motif for Cytotoxicity of 4-Phenyl-1-arylsulfonylimidazolidinones Using Thiadiazolidine-1, 1-Dioxide Analogs  

Kim, Il-Whan (College of Pharmacy, Chungnam National University)
Jung, Sang-Hun (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.25, no.4, 2002 , pp. 421-427 More about this Journal
Abstract
For probing the importance of planarity of imidazolidinone motif of 4-phenyl-1-(N-acylindoline-5-sulfonyl)imidazolidinones 1 for their cytotoxicity, 4-phenyl-1-(N-acylindoline-5-sulfonyl)[1,2,5]thiadiazolidine-1,1-dioxides 2 were prepared and their cytotoxicity were measured against human lung carcinoma (A549), human colon carcinoma (COLO205), human ovarian cancer (SK-OV-3), human leukemic cancer (K562), and murine colon adenocarcinoma (Colon26) cell lines in vitro. Although only carbonyl moiety of imidazolidinone ring was replaced with sulfonyl group, compounds 2 do not show any activity against all five cancer cell lines unlike 1. Therefore the planarity of imidazolidinone ring of 1 should be an important factor for their cytotoxic activity.
Keywords
4-Phenyl-1-(N-acylindoline-5-sulfonyl)imidazolidinones; Cytotoxicity; 4-Phenyl-1-(N-acylindoline-5-sulfonyl)[1,2,5]thiadiazolidine-1; 1-dioxides;
Citations & Related Records

Times Cited By Web Of Science : 7  (Related Records In Web of Science)
Times Cited By SCOPUS : 8
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