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Effect of Vehicles and Enhancers on the In Vitro Permeation of Melatonin through Hairless Mouse Skin  

Gwak, Hye-Sun (Laboratory of Pharmaceutics, College of Pharmacy, Dongduk Women′s University)
Kim, Seung-Ung (Laboratory of Pharmaceutics, College of Pharmacy, Dongduk Women′s University)
Chun, In-Koo (Laboratory of Pharmaceutics, College of Pharmacy, Dongduk Women′s University)
Publication Information
Archives of Pharmacal Research / v.25, no.3, 2002 , pp. 392-399 More about this Journal
Abstract
The effects of vehicles and penetration enhancers on the in vitro permeation of melatonin through dorsal hairless mouse skin were investigated. Propylene glycol laurate (PGL), isopropyl myristate (IPM), propylene glycol monolaurate (PGML) and propylene glycol monocaprylate (PGMC) showed high permeation fluxes and PGL, PGML and PGMC decreased lag time significantly. In both of the binary co-solvents of diethylene glycol monoethyl ether (DGME)-PGL and DGME-IPM, the highest fluxes were achieved at 20% of DGME, which were $10.5{\pm}1.5$ and $9.1{\pm}2.4{\;}{\mu\textrm{g}}/cm^2/h$, respectively. Among fatty acids used as a permeation enhancer, capric acid and oleic acid in DGME-PGL (80:20 v/v) showed relatively high enhancing effects. Capric acid also shortened the lag time of melatonin from $2.4{\pm}0.7{\;}to{\;}1.3{\pm}0.2{\;}h$. Oleic acid, however, failed to shorten the lag time. Therefore, for effective solution formulations in terms of permeation flux and lag time, capric acid-containing DGME-PGL (80 : 20 v/v) could be used to enhance the skin permeation of melatonin.
Keywords
Vehicles; Penetration enhancers; Melatonin; Permeation fluxes; Lag time;
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