Effects of Sophoraflavanone G, a Prenylated Flavonoid from Sophora Flavescens, on Cyclooxygenase-2 and In Vivo Inflammatory Response
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Kim, Dong-Wook
(College of Pharmacy, Kangwon National University)
Chi, Yeon-Sook (College of Pharmacy, Kangwon National University) Son, Kun-Ho (Dept. Food Nutri., Andong National University) Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University) Kim, Ju-Sun (Natural Products Res. Inst., Seoul National University) Kang, Sam-Sik (Natural Products Res. Inst., Seoul National University) Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) |
1 | Noreen, Y., Serrano, G., Perera, P., and Bohlin, L., Flavan-3-ols isolated from some medicinal plants inhibiting COX-I and COX-2 catalyzed prostaglandin biosynthesis. Planta Med., 64,520-524 (1998) DOI ScienceOn |
2 |
Chang, H. W., Baek, S. H., Chung, K. W., Son, K. H., Kim, H. P., and Kang, S. S., Inactivation of phospholipase |
3 | Cheon, B. S., Kim, Y. H., Son, K. H., Chang, H. W., Kang, S. S., and Kim, H. P., Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line, RAW 264.7. Planta Med., 66, 596-600 (2000) DOI ScienceOn |
4 | Harborne, J. B., and Williams, C. A., Advances in flavonoid research since 1992. Phytochem., 55,481-504 (2000) DOI ScienceOn |
5 | linuma, M., Ohyama, M., Tanaka, T., Mizuno, M., and Hong, S. K., Three 2',4',6'-trioxygenated flavanones in roots of Echinosophora koreensis. Phytochem., 31,2855-2858 (1992) DOI ScienceOn |
6 | Kimura, Y., Okuda, H., Nomura, T., Fukai, T., and Arichi, S., Effects of phenolic constituents from the mulberry tree on arachidonate metabolism in rat platelets. J. Nat. Prod., 49, 639-644 (1986b) DOI PUBMED |
7 | Liang, Y-C., Huang, Y-T., Tsai, S-H., Shiau, S-Y., Chen, C-F., and Lin, J-K., Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis, 20, 1945-1952 (1999) DOI ScienceOn |
8 | Kim, H. K., Namgoong, S. Y., and Kim, H. P., Anti-inflammatory activity of flavonoids: Mice ear edema inhibition. Arch. Pharm. Res., 16, 18-24 (1993) DOI ScienceOn |
9 | Reddy, G. R., Ueda, N., Hada, T., Sackeyfio, A. C., Yamamoto, S., Hano, Y, Aida, M., and Nomura, T., A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibition. Biochem. Pharmacol., 41,115-118 (1991) DOI ScienceOn |
10 | Mossman, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assays. J. Immunol. Methods, 65, 55-63 (1983) DOI PUBMED ScienceOn |
11 | Chi, Y S., Jong, H. G., Son, K. H., Chang, H. W, Kang, S. S., and Kim, H. P., Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: Cyclooxygenases and lipoxygenases. Biochem. Pharmacol., 62, 1185-1191 (2001 a) |
12 | Kim, H. K., Cheon, B. S., Kim, Y. H., and Kim, H. P., Effects of naturally-occurring flavonoids on nitric oxide production in the macrophage cell line RAW264.7 and their structural-activity relationships. Biochem. Pharmacol., 58, 759-765 (1999) DOI PUBMED ScienceOn |
13 | linuma, M., Ohyama, M., Tanaka, T., Mizuno, M., and Hong, S. K., An isoflavanone from roots of Echinosophora koreensis. Phytochem., 30, 3153-3154(1991) DOI ScienceOn |
14 | Kim, C. M., Ebizuka, Y, and Sankawa, U., Two new isoflavonoids from Echinosophora koreensis Nakai and structure revision of sophoronol. Chem. Pharm. Bull., 37, 2879-2881 (1989) DOI |
15 | Chi, Y. S., Cheon, B. S., and Kim, H. P., Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Biochem. Pharmacol., 61, 1195-1203 (2001 b) DOI PUBMED ScienceOn |
16 | Kang, S. S., Kim, J. S., Son, K. H., Chang, H. W., and Kim, H. P., A new prenylated flavanone from the roots of Sophora flavescens. Fitoterapia, 71, 511-515(2000) DOI ScienceOn |
17 |
Lindahl, M., and Tagesson, C., Selective inhibition of group II phospholipase |
18 | Kimura, Y., Okuda, H., Nomura, T., Fukai, T., and Arichi, S., Effects of flavonoids and related compounds from mulberry tree on arachidonate metabolism in rat platelet homogenates. Chem. Pharm. Bull., 34,1223-1227 (1986a) DOI PUBMED ScienceOn |
19 | Wirter, C. A., Risley, E. A., and Nuss, G. W., Carrageenan-induced edema in the hindpaw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med., 111, 544-547(1962) |
20 | Needleman, P., and Isakson, P., The discovery and function of COX-2. J. Rheumatol., 24 (Suppl.49),6-8 (1997) PUBMED |
21 | Kim, H. P., Son, K. H., Chang, H. W., and Kang, S. S., Effects of naturally occurring flavonoids on inflammatory responses and their action mechanisms. Nat. Prod. Sci., 6, 170-178(2000) |
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