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Anti-Platelet Effect of the Constituents Isolated from the Barks and Fruits of Magnolia obovata  

Pyo, Mi-Kyung (Natural Products Research Institute, Seoul National University)
Lee, Yong-Yook (Natural Products Research Institute, Seoul National University)
Yunchoi, Hye-Sook (Natural Products Research Institute, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.25, no.3, 2002 , pp. 325-328 More about this Journal
Abstract
In the course of our work on anti-platelet constituents from plants, five phenolic compounds, magnolol, honokiol, obovatol, methyl caffeate, and syringin, were isolated from the methanol extracts of the barks and fruits of Magnolia obovata. The compounds were identified based on the spectroscopic data. Methyl caffeate was isolated for the first time from the genus Magnolia and it showed 3∼4-folds higher potency than ASA. The activities of obovatol and honokiol were comparable to ASA. Magnolol and syringin showed only very mild inhibitory effects to all the stimulators.
Keywords
Magnolia obovata; Methyl caffeate; Magnolol; Honokiol; Obovatol; Anti-platelet;
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Times Cited By Web Of Science : 43  (Related Records In Web of Science)
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1 Comte, G., Chulia, A. J., Vercauteren, J. and Allais, D. P., Phenylpropane glycosides from Juniperus phoenicea. Planta Med., 61, 88-89 (1996)
2 Fujita, M., Itokawa, H. and Sashida, Y., Honokiol, a new phenolic compound isolated from the bark of Magnolia obovata. Chem. Pharm. Bull., 20(1), 212-213 (1972)   DOI
3 Yun-Choi, H. S., Park, K. M., Pyo, M. K., Epinephrine induced platelet aggregation in rat platelet-rich plasma. Throm. Res., 100, 511-518 (2000)   DOI   ScienceOn
4 Ito, K., lida, T., Ichino, K., Tsunezuka, M., Hattori, M., and Namba, T., Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata T$HUNB$, Chem. Pharm. Bull., 30(9), 3347-3353 (1982)   DOI   PUBMED   ScienceOn
5 Chang, W.C. and Hsu, F. L., Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leukot. Essent. Fatty Acids, 45(4),307-312 (1992)   DOI   ScienceOn
6 Fujita, M., Itokawa, H., and Sashida, Y., Studies on the components of Magnolia obovata Thunb. Occurrence of magnolol and honokiol in M. obovata and other allied plants. Yakugaku Zasshi, 93(4),429-34 (1973)   DOI   PUBMED
7 Hanasaki, K., Nakano, T. and Arita, H., Two phasic generation of thromboxane A$_2$ by the action of collagen on rat platelets. Throm. Res. 46, 425-436 (1981)
8 Koshihara, Y., Neichi, T., Urota, S., Lao, A., Fujimoto, Y., Tatsuno, T., Caffeic acid is a selective inhibitor for leukotriene biosynthesis. Biochim. Biophys. Acta., 792 (1), 92-97 (1984)   DOI   PUBMED   ScienceOn
9 Martinez, V., Barbera, O., Sanchez-Parareda, J. and Marco J. A., Phenolic and acetylic metabolites from Artemisia assoana. Phytochemistry, 26(9), 2619-2624 (1987)   DOI   ScienceOn
10 Nagao, T., Abe, F., and Okabe, H., Antiproliferative constituents in the plants in the plants 7. Leaves of Clerodendron bugei and leaves and bark of C. trichotomum. Bio. Pharm. Bull., 24(11) 1338-1341 (2001)   DOI   ScienceOn
11 Pouchert, C. J., and Behnke, J., The Aldrich Library of {^13} and $^1$FT NMR Spectra, vol. 2, Aldrich Chem. Comp. Inc. 1993, p755
12 Xiang, T., Xiong, Q. B., Ketut A. I., Tezuka, Y., Nagaoka, T., and Wu, L. J., Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei. Planta Med., 67, 322-325 (2001)   DOI   ScienceOn
13 Seiichi, I., Kenzo, H., Hitoshi, H., Tamiko, O., Takeshi, K., Manabu, H., and Teruo, Y., Studies on non-sesquiterpenoid constituents of Gaillardia.. Less lipopholic substances methylcaffeate as an antitumor catecholic. Chem. Pharm. Bull. 32(3),1135-1141 (1984).   DOI   ScienceOn
14 Sugii, Y., Constituent of the bark of Magnolia officinalis Rehd. Et Wils. And M. obovata Thunb. Yakugaku Zasshi, 50, 183-217 (1930)   DOI
15 Teng, C.M., Chen, C.C., Ko, F.N., Lee, L.G., Huang, T.F., Chen, Y.D. and Hsu, H.Y., Two antiplatelet agents from Magnolia officinalis. Thromb. Res., 50(6), 757-765 (1988)   DOI   ScienceOn
16 Bourne, E. J., Macleod, N. J., Pridham, J. B., The identification of naturally occurring cinnamic acid derivatives, Phyto-chemistry, 2, 225-230 (1963)
17 Etzenhouser, B., Hansch, C., Kapur, S. and Selassie, C. D., Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids, Bioorg. Med. Chem., 9, 199-209 (2001)   DOI   ScienceOn
18 Sinakos, Z. and Caen, J.P., Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog). A comparative study. J. Lab. & Clin. Med., 17,99-111 (1967)
19 Makino, T., Ono, T., Muso, E., and Honda, G., Inhibitory effects of Perilla frutescens and its phenolic constituents on cultured murine mesnagial cell proliferation, Planta Med., 64, 541-545(1998)   DOI   ScienceOn
20 Marco, J. A., Barbera, O., Rodriguez, S., Domingo, C. and Adell, J., Flavonoids and other phenolics from Artemisia hispanica. Phytochemistry, 27 (10), 3155-3159 (1988)   DOI   ScienceOn
21 Lee, I. R. and Yang, M. Y., Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell. Arch. Pharm. Res., 17 (6), 476-479 (1994)   DOI   ScienceOn
22 Niwa, M., Iwadare, Y., Wu, Y. C. and Hirata, Y., Two new phenylpropanoid glycosides from Wikstroemia sikokiana. Chem. Pharm. Bull., 36(3),1158-1161 (1988)   DOI
23 Kwon, B. M., Kim, M. K., Lee, S. H., Kim, J. A., Lee, I. R., Kim, Y. K., and Bok, S. H., Acyl-CoA: Cholesterol acytransferase inhibitors from Magnolia obovata. Planta Med., 63, 550-550(1997)   DOI   ScienceOn
24 Malingre, S. T. M. and Van, Os F. H. L., Iridoid and phenolic glycosides of Fraxinus griffithii. Phytochemistry, 17, 564-564(1978)   DOI   ScienceOn