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Antioxidative Flavonoids from Leaves of Carthamus tinctorius  

Lee, Jun-Young (Department of Food Science and Nutrition, Catholic University of Daegu)
Chang, Eun-Ju (Department of Food Science and Nutrition, Catholic University of Daegu)
Kim, Hyo-Jin (Department of Food Science and Nutrition, Catholic University of Daegu)
Park, Jun-Hong (Uisong Medicinal Plant Experiment Station, Gyeongbuk Provincial A.T.A.)
Choi, Sang-Won (Department of Food Science and Nutrition, Catholic University of Daegu)
Publication Information
Archives of Pharmacal Research / v.25, no.3, 2002 , pp. 313-319 More about this Journal
Abstract
A total of eight flavonoids (1-8), including a novel $quercetin-7-o-(6"-o-acetyl)-{\beta}-D-glucopyranoside$ (6) and seven known flavonoids, luteolin (1), quercetin (2), luteolin $7-o-{\beta}-D-glucopyranoside$ (3), $luteolin-7-o-(6"-Ο-acetyl)-{\beta}-D-glucopyranoside$ (4) quercetin $7-o-{\beta}-D-glucopyranoside$ (5), acacetin 7-o-{\beta}-D-glucuronide (7) and apigenin-6-C-{\beta}-D-glucopyrano $syl-8-C-{\beta}-D-glucopyranoside$ (8), have been isolated from the leaves of the safflower (Carthamus tinctorius L.) and identified on the basis of spectroscopic and chemical studies. The antioxidative activity of these flavonoids was evaluated against 2-deoxyribose degradation and rat liver microsomal lipid peroxidation induced by hydroxyl radicals generated via a Fenton-type reaction. Among these flavonoids, luteolin-acetyl-glucoside (4) and quercetin-acetyl-glucoside (6) showed potent antioxidative activities against 2-deoxyribose degradation and lipid peroxidation in rat liver microsomes. Luteolin (1), quercetin (2), and their corresponding glycosides (3 & 5) also exhibited strong antioxidative activity, while acacetin glucuronide (7) and apigenin-6,8-di-C-glucoside (8) were relatively less active.
Keywords
Carthamus tinctorius; Compositae; Flavonoids; 2-Deoxyribose degradation; microsomal lipid peroxidation; Antioxidative activity;
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Times Cited By Web Of Science : 19  (Related Records In Web of Science)
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