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Effect of Butanol Fraction of Panax ginseng Head on Gastric Lesion and Ulcer  

Jeong, Choon-Sik (College of Pharmacy, Duksung Women′s University)
Publication Information
Archives of Pharmacal Research / v.25, no.1, 2002 , pp. 61-66 More about this Journal
Abstract
From our previous result that Panax ginseng head extract had inhibition of gastric damages, the extract was fractionated. Among the hexane, chloroform, butanol and water fractions, butanol fraction Showed the most potent inhibition of HCl.ethanol-induced gastric lesion, aspirin-induced gastric ulcer, acetic acid-induced ulcer and Shay ulcer. Butanol fraction showed significant increase in mucin secretion, and inhibited malondialdehyde (MDA) and $H^{+}/K^{+}ATPase$ activity in the stomach. This results indicate that the effectiveness of the fraction on gastric damages might be related to inhibition of acid secretion, increment of mucin secretion and antioxidant property.
Keywords
Head of Panax ginsengl; Butanol Fraction; Gastric lesion; Ulcer;
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1 Hur, J., Dongeui Bogam, Namsan-dang, Seoul, 1989
2 Uchiyama, M., Suzuki, Y., and Fukuzawa, K., Biochemical studies of physiological function of tocopherolactone. Yakugaku Zasshi, 88, 678-683 (1968)   DOI   PUBMED
3 Brzozowski, T., Konturek, P. C., Konturek, S. J., Sliwowski, Z., Pajdo, R., Drozdowicz, D., Ptak, A., and Hahn, E. G., Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. Microsc. Res. Tech. 53, 343-53 (2001)   DOI   ScienceOn
4 Chung, C. S., Jung, K. H., and Lee, E. B. Antigastritic and antiulcer actions of the extract of head of Panax ginseng Radix, Kor. J. Pharmacogn., 27, 295-300 (1996)
5 Wallmark, B., Larsson, H., and Humble, L., The relationship between gastric acid secretion and gastric H$^+$,K$^+$-ATPase activity. J. Biol. Chem. 260 13681-13684 (1985)   PUBMED
6 Fiske, C. H. and Subbarow, Y., The colorimetric determination of phosphrous. J. Biol. Chem. 66, 375-400 (1924)
7 Mizui, T. and Dodeuchi, M., Effect of polyamines on acidified ethanol-induced gastric lesion in rats. Jpn. J. Pharmacal., 33, 939-945 (1983)   DOI
8 Robert, A., Nezamis, J. E., Lancaster, C., and Hanchar, A. J., Cytoprotection by prostaglandins in rats. Gastroenterol. 77, 433-443, 1979
9 Saccomani G., Stewart, H. B., Shaw, D., Lewin, M., and Sachs, G., Characterization of gastric mucosal membranes. IX. Fractionation and purification of $K^{+}$,ATPase containing vesicles by zonal centrifugation and free-flow electrophoresis technique. Biochem. Biaphys. Acta., 465, 311-330 (1977)   DOI   ScienceOn
10 Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J. Protein measurement with the phenol reagent, J. Biol, Chem. 193, 265-275 (1951)
11 Shay, H., Komarov, S. A., Fels, S. S., and Meranze, D., A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol., 4, 43-61 (1945)
12 Kitagawa, H., Takeda, F., and Kohei, H. A simple method for estimation of gastric mucus and effect of antiulcerogenic agents on the decrease in mucus during water-immersion stress in the rats. Arzneim-Forsch., 36, 1240-1244, 1986
13 Okabe, S., Takeuchi, K., Nakamura, K., and Takagi, K., Pathogenesis of gastric lesion induced by aspirin in the pylorusligated rat. Jpn. J. Pharmacol., 24, 363 (1974)   DOI   PUBMED
14 Chung, S. H, Choi, C. G., and Park, S. H., Comparisons between white Ginseng Radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch. Pharm. Res. 24, 214-218 (2001)   DOI   ScienceOn
15 Munwha Broading Corporation (ed.), Korean Folk Medicinal Therapeutics, Keumbak Publish Co. Ltd., Seoul, Korea, p57, 1987
16 Guth, P. H., Aures, D., and Paulsen, G., Topical Aspirin Plus HCI Gastric Lesions in the Rat. Gastroenterol., 76, 88 (1979)
17 Takagi, K., Okabe, S., and Saziki, R. 1969. A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Jpn. ,J. Pharmacol. 19, 418-426 (1969)   DOI
18 Jiansu New College Medicine Eds, Encyclopedia of Chiness Herbs, Shanghai Science & Technology Publication, Shanghai, 1977
19 Ohkawa, H., Ohishi, N., and Yagi, K., Assay for lipid peroxidase in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358 (1979)   DOI   ScienceOn
20 Konturek, S. J., Role of prostaglandins in the formation of aspirin-induced gastric ulcers. Gastroenterol., 80, 4 (1981)
21 Seiki, M., Ukei, S., Tanaka, Y., and Soeda, M., Studies of antiulcer effects of a new compound, zinc L-carnosine (Z-103). Folia Pharmacol. Japan, 95, 257 (1990)   DOI   ScienceOn