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Stereoselective Syntheses of ($\pm$)-Epibatidine Analogues  

Kim, Yong-Hyun (College of Pharmacy, SungKyunKwan University)
Won, Do-Youn (College of Pharmacy, SungKyunKwan University)
Oh, Chang-Young (College of Pharmacy, SungKyunKwan University)
Lee, Kee-Young (College of Pharmacy, SungKyunKwan University)
Lee, Yiu-Suk (College of Pharmacy, SungKyunKwan University)
Woo, Nam-Tae (College of Pharmacy, SungKyunKwan University)
Park, Young-Ho (College of Pharmacy, SungKyunKwan University)
Park, Hyun-Ju (College of Pharmacy, SungKyunKwan University)
Ham, Won-Hun (College of Pharmacy, SungKyunKwan University)
Publication Information
Archives of Pharmacal Research / v.25, no.1, 2002 , pp. 45-48 More about this Journal
Abstract
Stereoselective syntheses of ($\pm$)-epibatidine analogues 2, which contain the 8-azabicyclo[3.2.1]octane ring system, were achieved by using palladium-catalyzed cross-coupling reaction from 4 and the analgesic activity was tested by Mouse writhing antinociceptive assay.
Keywords
Alkaloids; Epibatidine; Analgesics; Palladium; Stereocontrol;
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