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http://dx.doi.org/10.3839/jabc.2021.053

Phytochemical constituents from the aerial parts of Salvia plebeia  

Paje, Leo Adrianne (Department of Plant Science and Technology, Chung-Ang University)
Lee, Hak-Dong (Department of Plant Science and Technology, Chung-Ang University)
Choi, Jungwon (Department of Plant Science and Technology, Chung-Ang University)
Kim, Juree (Department of Plant Science and Technology, Chung-Ang University)
Kim, Ki Hyun (School of Pharmacy, Sungkyunkwan University)
Yu, A Ram (Department of Plant Science and Technology, Chung-Ang University)
Bae, Min-Jung (Technical Assistance Department, The Food Industry Promotional Agency of Korea)
Lee, Sanghyun (Department of Plant Science and Technology, Chung-Ang University)
Publication Information
Journal of Applied Biological Chemistry / v.64, no.4, 2021 , pp. 391-397 More about this Journal
Abstract
Four compounds were isolated from Salvia plebeia aerial parts. Silica gel open column chromatography with a gradient elution system was used to isolate and purify these compounds. Nuclear magnetic resonance spectroscopy and mass spectroscopy were used for structural elucidation and identification, while electronic circular dichroism was used to confirm the absolute configuration. The structures were determined to be 𝛽-sitosterol (1), (-)-1S,5S,8S,10R-1-acetoxy-8-hydroxy-2-oxoeudesman-3,7(11)-dien-8,12-olide (2), ursolic acid (3), and N-methylhydroxylamine (4). Compounds 2 and 4 were isolated for the first time from this plant. Compound 2 was quantitatively analyzed via HPLC/UV. The results showed that the methanol extract of S. plebeia had a higher content of compound 2 (1.20 mg/g) than the ethanol extract (0.55 mg/g). This study could be used as a preliminary step in conducting HPLC/UV analysis of sesquiterpenoids in S. plebeia extract to assess their bioavailability and potency.
Keywords
Eudesmane-type sesquiterpenoid; N-methylhydroxylamine; Salvia plebeia;
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