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http://dx.doi.org/10.3839/jabc.2021.006

Neuroprotective and anti-inflammatory activity of marine sponge extract and HPLC profiling of its components  

Kim, Da-Eun (Natural Product Informatics Research Center, Korea Institute of Science and Technology)
Kim, Min-Seon (Natural Product Informatics Research Center, Korea Institute of Science and Technology)
An, Hye Suck (Marine Biology Research Division, National Marine Biodiversity Institute of Korea)
Lee, Jae Wook (Natural Product Research Center, Korea Institute of Science and Technology)
Park, Jin-Soo (Natural Product Informatics Research Center, Korea Institute of Science and Technology)
Publication Information
Journal of Applied Biological Chemistry / v.64, no.1, 2021 , pp. 33-38 More about this Journal
Abstract
Marine sponges contain pharmacologically attractive substances that exhibit strong cytotoxicity and are used as materials to isolate potential drug candidates. However, with a growing interest in marine ecosystem conservation, it is becoming increasingly difficult to gather a sponge for natural product research. To build a database to cope with this issue, we measured the neuroprotective and anti-inflammatory activity of 181 sponge extracts. As a result, we found 17 samples with neuroprotective effects and 14 samples with anti-inflammatory effects. In addition, high-performance liquid chromatography (HPLC) analysis was performed to compare the components contained in each sample, and based on HPLC profiles, a dendrogram according to similarity was created. The results of this study suggested the possibility of discovering the active compounds in the sponge and laid the basis for efficient research on the sponge.
Keywords
Anti-inflammatory activity; High-performance liquid chromatography profiling; Neuroprotective activity; Sponge;
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Times Cited By KSCI : 2  (Citation Analysis)
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