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http://dx.doi.org/10.3839/jabc.2021.004

Inhibitors of Antigen-induced Degranulation of RBL-2H3 Cells Isolated from Amomum tsao-ko  

Jeong, Wonsik (Bio-Center, Gyeonggido Business & Science Accelerator (GBSA))
Hong, Seong Su (Bio-Center, Gyeonggido Business & Science Accelerator (GBSA))
Park, Sun-Mi (Bio-Center, Gyeonggido Business & Science Accelerator (GBSA))
Lee, Jung A (Bio-Center, Gyeonggido Business & Science Accelerator (GBSA))
Park, Ju-Hyoung (College of Pharmacy, Dankook University)
Ahn, Eun-Kyung (Bio-Center, Gyeonggido Business & Science Accelerator (GBSA))
Choi, Chun Whan (Bio-Center, Gyeonggido Business & Science Accelerator (GBSA))
Oh, Joa Sub (College of Pharmacy, Dankook University)
Publication Information
Journal of Applied Biological Chemistry / v.64, no.1, 2021 , pp. 19-23 More about this Journal
Abstract
Bioactivity-guided fractionation of EtOH extract of the dried fruits of Amomum tsao-ko led to isolation of three compounds (1-3). Their structures were elucidated by spectroscopic methods (MS, 1D and 2D-NMR) and comparison with literature values, as naringenin-5-O-methyl ether (1), helichrysetin (2), and cardamomin (3). Compound 2 was obtained from the genus Amomum for the first time. Among them, compounds 2 and 3 inhibited on the release of β-hexosaminidase from RBL-2H3 cells, with 99.1 and 21.3% at the concentration of 50 μM, respectively.
Keywords
Amomum tsao-ko; ${\beta}$-hexosaminidase; Flavonoid; RBL-2H3;
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