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http://dx.doi.org/10.3839/jabc.2019.027

Antioxidant and anti-inflammatory activity of parts of Rhus javanica L.  

Choi, Ji-Soo (Department of Medicinal Plant Science, Jungwon University)
Han, Sang-Don (Department of Medicinal Plant Science, Jungwon University)
Jang, Tae-Won (Department of Medicinal Plant Resources, Andong National University)
Lee, Seung-Hyun (Industry-Academic Cooperation Foundation, Jungwon University)
Park, Jae-Ho (Department of Medicinal Plant Science, Jungwon University)
Publication Information
Journal of Applied Biological Chemistry / v.62, no.2, 2019 , pp. 195-202 More about this Journal
Abstract
Rhus javanica L. is Anacardiaceae plant distributed in East Asia. We evaluated the antioxidant activity and antiinflammatory effect of leaf, branch, root of ethyl acetate fraction from R. javanica. To confirm effective each extraction, The antioxidant activity was evaluated using 1,1-Diphenyl-2-picryl-hydrazyl and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) scavenging activity assays, and the anti-inflammatory activity was evaluated based on inhibitory activities on the protein and mRNA expression of iNOS and COX-2 in LPS-induced RAW264.7 cells. The phenolic compounds content of each extract was analyzed with Folin reagents and HPLC/PDA method. The gallic acids were identified and quantified. The roots of R. javanica showed strong antioxidant activity. Its total phenolic compounds content were higher than the orders. In addition, anti-inflammatory activity inhibited the protein and mRNA expression of nitric oxide production factor, following the same pattern as contents of phenolic compounds included gallic acid and its antioxidant activity. In conclusion, R. javanica showed effective antioxidant and anti-inflammatory activity. Especially, the roots were evaluated to be highly valuable as a natural resource for reducing inflammation.
Keywords
Antioxidant; Inducible nitric oxide synthase; Phenolic compounds; Rhus javanica;
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