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http://dx.doi.org/10.3839/jabc.2019.024

Inhibitory activity against biological activities and antimicrobial activity against pathogenic bacteria of extracts from Hericium erinaceus  

Kim, Myung-Uk (Gyeongbuk institute for marine bio-industry)
Lee, Eun-Ho (School of Food science & Biotechnology, Kyungpook National University)
Jung, Hee-Young (School of Applied Biosciences, Kyungpook National University)
Lee, Seung-Yeol (School of Applied Biosciences, Kyungpook National University)
Cho, Young-Je (School of Food science & Biotechnology, Kyungpook National University)
Publication Information
Journal of Applied Biological Chemistry / v.62, no.2, 2019 , pp. 173-179 More about this Journal
Abstract
The aim of this study is to investigate the biological activities of Hericium erinaceus. 1,1-Diphenyl-2-picrylhydrazyl radical scavenging activity of H. erinaceus extract was higher than positive control. The inhibitory activities of xanthin oxidase, ${\alpha}$-glucosidase, and hyaluronidase was measured as functional food activity, and inhibitory activities on collagenase, tyrosinase, and astringent effect as beauty food activity in water and ethanol extracts from H. erinaceus. In functional food activity, xanthin oxidase inhibitory activities at $50-200{\mu}g/mL$ phenolic concentration in ethanol extracts from H. erinaceus showed inhibitory activity in dose dependent manner. ${\alpha}$-Glucosidase inhibitory activities at $50{\mu}g/mL$ phenolic concentration showed high activity of higher than 80%. Inhibitory activities on hyaluronidase as anti-inflammation factor showed inhibition effect in dose dependent manner both in water and ethanol extracts. In beauty food activity, Inhibitory activities on collagenase at $200{\mu}g/mL$ phenolic concentration in water and ethanol extracts showed high activity to 65.09 and 58.38% dose dependently. Tyrosinase inhibitory activity in water extract showed 9.4-58.24%. Astringent activity as pore shrink effect in ethanol extracts also showed a very high activity of 18.94-100%. Antimicrobial activity on pathogenic bacteria was highly effective on Staphylococcus aureus, Salmonella enteritidis, Vibrio parahaemolyticus and Escherichia coli at 2.5 mg/mL or above. Therefore, the extracts from H. erinaceus can be used as a functional food and beauty food resources and natural antimicrobial agent on pathogenic bacteria in food.
Keywords
Antimicrobial activity; Biological enzyme; Hericium rinaceus; Inhibition; Pathogenic bacteria;
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1 Choi JH, HA TM, Kim YH, Rho YD (1996) Studies on the main factors affecting the mycelial growth of Phellinus lintenus. Kor J Mycol 24: 214-222
2 Tsukagoshi S, Ohashi F (1974) Protein-bound polysaccharide preparation, PS-K, effective against mouse sarcoma-180 and rat ascites hepatoma AH-13 by oral use. Gann 65: 557-558
3 Kang MG, Bolormaa Z, Lee JS, Seo GS, Lee JS (2011) Antihypertensive activity and anti-gout activity of mushroom Sarcodon aspratus. Kor J Mycol 39: 53-56   DOI
4 Hyun KW, Jeong SC, Lee DH, Park JS, Lee JS (2006) Isolation and characteriaztion of a noble platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus. Peptides 27: 1173-1178   DOI
5 Shin HH, Choi HS (1998) Purification and partial characterization of a metalloprotease in Flammulina velutipes. J Micrbiol 36: 20-25
6 Kim JH, Kim YS (2001) Characterization of a metalloenzyme from a wild mushroom, Tricholoma saponaceum. Biosci Biotech Biochem 65: 356-362   DOI
7 Kawagishi T, Shimada A, Hosokawa S, Mori H, Okamoto K, Sakamoto H, Ishiguro Y, Sakemi S, Bordner J, Kojima N, Furukawa S (1996) Erinacines E, F and G, stimulatores of verve growth factor (NGF)-synthesis, from the mycelia of Hericum erinaceus. Tetrahedron Lett 37: 7399-7402   DOI
8 Park WH, Lee HD (1999) An illustrated guide book of colorful Korean medicinal mushroom, p. 442-443, Gyohaksa, Korea
9 Yanmaguchi M, Yearul KA (1987) Effect of shitake and maitake mushroom on blood pressure and plasm lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol 33: 341-345   DOI
10 Yearul KA, Shuichi K (1989) Dietary mushroom reduce blood pressure in spontaneously hypertensive rat. J Nutr Sci Vitaminol 35: 91-96   DOI
11 Mizuno T, Wasa T, Ito H, Suzuki C, Ukai N (1992) Antitumor active polysaccharides isolated from the fruiting body of Hericum erinaceus: an edible and medicinal mushroom called Yamabushitake or Houtou. Biosci Biotech Biochem 56: 347-348   DOI
12 Ryu SR, Lee WY, Ka KH (2009) Comparative study on the sawdust cultivation and the antioxidant of Hericum spp. Kor J Mycol 37: 80-85   DOI
13 Kawagishi H, Shimada A, Hosokawa S, Mori H, Sakamoto H, Ishiguro Y, Sakemi S, Bordner J, Kojima N, Furukawa S (1996) Erinacines E, F and G stimulator of nerve growth factor (NGF)-synthesis from the mycelia of Hericum erinaceus. Tetrahedon Letters 37: 7399-7402   DOI
14 Ju JC, Shin JH, Lee SJ, Cho HS, Sung NJ (2006) Antioxidative activity of hot water extracts from medicinal plants. J Kor Soc Food Sci Nutr 35: 7-14   DOI
15 Folin O, Denis W (1912) On phoshotungstic-phosphomolybdic compounds as color reagents. J Biol Chem 12: 239-243   DOI
16 Wunsch E, Heidrich HG (1963) Zur quantitativen bestimmung der kollagenase. Hoppe-Seyler'eyle Physiol Chem 333: 149-151   DOI
17 Blois MS (1958) Antioxidant determination by the use of stable free radical. Nature 181: 1199-1200   DOI
18 Stirpe F, della Corte E (1969) The regulation of rat liver xanthine oxidase. J Biol Chem 244: 3855-3863   DOI
19 Tibbot BK, Skadsen RW (1996) Molecular cloning and characterization of a gibberellin-inducible, putative a-glucosidase gene from barley. Plant Mol Biol 30: 229-241   DOI
20 Dorfman A, Ott ML (1948) A turbidimetric method for the assay of hyaluronidase. J Biol Chem 172: 367-375   DOI
21 Hearing VJ Jr (1987) Mammalian monophenol monooxygenase (tyrosinase): purification, properties, and reactions catalyzed. Methods Enzymol 142: 154-165   DOI
22 Lee JT, Jeong YS, An BJ (2002) Physiological activity of Salicornia herbacea and its application for cosmetic materials. Kor J Herb 17: 51-60
23 Davidson PM, Parish ME (1989) Methods for testing the efficacy of food antimicrobials. Food Technol 43: 148-155
24 Choi HS, Kim MG, Shin JJ, Pack JM, Lee JS (2003) The antioxidant activities of the some commercial teas. J Kor Soc Food Sci Nutr 32: 723-727   DOI
25 Farag RS, Badei AZMA, Hewedi FM, El-Baroty GSA (1989) Antioxidant activity of some spice essential oils on linoleic acid oxidation in aqueous media. J Am Oil Chem Soc 66: 792-799   DOI
26 Frei B (1994) Natural antioxidants in human health and disease. Academic Press Publisher, p 40-55, Cambridge, Massachusetts, USA
27 Baker JF, Schumacher HR (2010) Update on gout and hyperuricemia. Int J Clin Pract 64: 371-377   DOI
28 McDougall GJ, Stewart D (2005) The inhibitory effects of berry polyphenols on digestive enzymes. Bio Factors 23: 189-195
29 Lee EH, Park HJ, Kim NH, Hong EJ, Park MJ, Lee SH, Kim MU, An BJ, Cho YJ (2016) Biological activities of Aster scaber extracts. Kor J Food Preserv 23: 393-401   DOI
30 Hanefeld M (1998) The role of acarbose in the treatment of non-insulindependent diabetes mellitus. J Diabetes Complications 12: 228-237   DOI
31 Ghosh P (1994) The role of hyaluronic acid in health and disease: interactions with cells, cartilage and components of synovial fluid. Clin Exp Rheumatol 12: 75-82
32 Giacomoni PU, Rein G (2001) Factors of skin ageing share common mechanism. Biogerontol 2: 219-229   DOI
33 No JK, Soung DY, Kim YJ, Shim KH, Jun YS, Rhee SH, Yokozawa T, Chung HY (1999) Inhibition of tyrosinase by green tea components. Life Sci 65: PL241-246
34 Hamilton AJ, Gomez BL (2002) Melanins in fungal pathogens. J Med Microbiol 51: 189-191   DOI
35 Tsuji N, Moriwaki S, Suzuki Y, Takema Y, Imokawa G (2001) The role of elastases secreted by fibroblast in wrinkle formation: implication through selective inhibition of elastase activity. Photochem Photobiol 74: 283-290   DOI
36 Son CY, Beak IH, Song GY, Kang JS, Kwon KI (2009) Pharmacological effect of decursin and decursinol angelate from Angelica gigas Nakai. Yakhak Hoeji 53: 303-313
37 Huang MT, Ho CT, Lee CY (1992) Phenolic compounds in food and their effects on health. ACS publisher, p.48-52, Washington, DC, USA
38 Kim JS, Oh CH, Jeon H, Lee KS, Ma SY (2002) Immunoregulatory property of fruit-extracts of Cornus kousa Burg. Kor J Med Crop Sci 10: 327-332
39 Kim KB, Jo BS, Park HJ, Park KT, An BJ, Ahn DH, Kim MU, Chae JW, Cho YJ (2012) Healthy functional food properties of phenolic compounds isolated from Ulmus pumilia. Kor J Food Preserv 19: 909-918   DOI