Browse > Article
http://dx.doi.org/10.3839/jabc.2019.013

Analysis of major ginsenosides in various ginseng samples  

Lee, Dong Gu (Department of Plant Science and Technology, Chung-Ang University)
Lee, Ju Sung (Department of Plant Science and Technology, Chung-Ang University)
Kim, Kyung-Tack (Korea Food Research Institute)
Kim, Hyun Young (Department of Food Science, Gyeongnam National University of Science and Technology)
Lee, Sanghyun (Department of Plant Science and Technology, Chung-Ang University)
Publication Information
Journal of Applied Biological Chemistry / v.62, no.1, 2019 , pp. 87-91 More about this Journal
Abstract
The contents of major ginsenosides (ginsenosides Rb1, ginsenoside Rc, ginsenoside Rd, ginsenoside Re, ginsenoside Rf, and ginsenoside Rg1) in ginseng cultivated in different areas in Korea, ginseng that underwent different cultivation processes and ages, and ginseng cultivated in different countries were determined using high-performance liquid chromatography equipped with UV/VIS detector. Ginsenoside Rc was the most abundant ginsenoside in all different ginseng samples. The highest total concentration of major ginsenosides was found in the ginseng cultivated in Jinan (0.931 mg/g) and 4-year grown red ginseng (1.785 mg/g). Major ginsenosides were the most abundant in Korean ginseng (1.264 mg/g), compared to those in Chinese and American ginseng. The results of this study showed the different contents of major ginsenosides in the ginseng samples tested and emphasized which sample could contain high yield of ginsenosides.
Keywords
Ginsenoside; Panax species; Quantitative analysis;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
연도 인용수 순위
1 Furukawa T, Bai C-X, Kaihara A, Ozaki E, Kawano T, Nakaya Y, Awais M, Sato M, Umezawa Y, Kurokawa J (2006) Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. Mol Pharmacol 70: 1916-1924   DOI
2 Lee SA, Bae B-S, Park H-W, Ahn N-G, Cho B-G, Cho Y-L, Kwak Y-S (2015) Characterization of Korean red ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition. J Ginseng Res 39: 384-391   DOI
3 Chung I-M, Lim J-J, Ahn M-S, Jeong H-N, An T-J (2016) Comparative phenolic compound profiles and antioxidative activity of the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) according to cultivation years. J Ginseng Res 40: 68-75   DOI
4 Kim JH, Yi YS, Kim MY, Cho JY (2017) Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J Ginseng Res 41: 435-443   DOI
5 Shi X-J, Yang W-Z, Qiu S, Yao C-I, Shen Y, Pan H-Q, Bi Q-R, Yang M, Wu W-Y, Guo D-A (2017) An in-source multiple collision-neutral loss filtering based nontargeted metabolomics approach for the comprehensive analysis of malonyl-ginsenosides from Panax ginseng, P. quinquefolius, and P. notoginseng. Anal Chim Acta 952: 59-70   DOI
6 Zhang K, Wang X, Ding L, Li J, Qu CL, Chen LG, Jin HY, Zhang HQ (2008) Determination of seven major ginsenosides in different Panax quinquefolius L. (American ginseng) with different ages. Chem Res Chinese Universities 24: 707-711   DOI
7 Lee CH, Kim JH (2014) A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases. J Ginseng Res 38: 161-166   DOI
8 Yang W, Qiao X, Li K, Fan J, Bo T, Guo D-A, Ye M (2016) Identification and differentiation of Panax ginseng, Panax quinqefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers. Acta Pharm Sin B 6: 568-575   DOI
9 Ru W, Wang D, Xu Y, He X, Sun Y-E, Qian L, Zhou X, Qin Y (2015) Chemical constituents and bioactivities of Panax ginseng (C.A. Mey.). Drug Discov Ther 9: 23-32   DOI
10 Park SE, Na CS, Yoo SA, Seo SH, Son HS (2017) Biotransformation of major ginsenosides in ginsenoside model culture by lactic acid bacteria. J Ginseng Res 41: 36-42   DOI
11 Lee DG, Lee J, Kim K-T, Lee S-W, Kim Y-O, Cho I-H, Kim H-J, Park C-G, Lee S (2018) High-performance liquid chromatography analysis of phytosterols in Panax ginseng root grown under different conditions. J Ginseng Res 42: 16-20   DOI
12 Hanagata N (2012) Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system. Int J Nanomed 7: 2181-2195   DOI
13 Jang H-E, Jung H, Mok H (2017) Cleavable conjugation of CpG oligodeoxynucleotides onto microparticles for facile release and cytokine induction in macrophages. Appl Biol Chem 60: 321-326   DOI
14 Castro-Aceituno V, Ahn S, Simu SY, Singh P, Mathiyalagan R, Lee HA, Yang DC (2016) Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells. Biomed Pharmacother 84: 158-165   DOI
15 Lee DG, Lee J, Yang S, Kim K-T, Lee S (2015) Identification of dammarane-type triterpenoid saponins from the roots of Panax ginseng. Nat Prod Sci 21: 111-121
16 Kim DH, Park CH, Park D, Choi YJ, Park MH, Chung KW, Kim SR, Lee JS, Chung HY (2014) Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress. Arch Pharm Res 37: 813-820   DOI
17 Ahn SI, Kim SK, Yang BW, Lee ES, Kang CS, Hahm YT (2016) Analysis of ginsenosides and non-saponin components of red ginseng from landraces and new varieties. Korean J Hortic Sci Technol 34: 790-798
18 Kim SN, Ha YW, Shin H, Son SH, Wu SJ, Kim YS (2007) Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. J Pharm Biomed Anal 45: 164-170   DOI
19 Lee CR, Whang WK, Shin CG, Lee HS, Han ST, Im BO, Ko SK (2004) Comparison of ginsenoside composition and contents in fresh ginseng roots cultivated in Korea, Japan, and China at various ages. Korean J Food Sci Technol 36: 847-850
20 Lee SA, Liuting, Jo HK, Im BO, Cho SH, Whang WK, Ko SK (2010) The comparison of ginsenoside composition contents in notoginseng radix (Sanchi) on various parts and ages. Kor J Pharmacogn 41: 319-322
21 Lee SM (2014) Thermal conversion pathways of ginsenosides in red ginseng processing. Nat Prod Sci 20: 119-125