Bioconversion of Gentiana scabra Bunge increases the anti-inflammatory effect in RAW 264.7 cells via MAP kinases and NF-κB pathway |
Kim, Min-A
(National Development Institute of Korean Medicine)
Lee, Han-Saem (National Development Institute of Korean Medicine) Chon, So-Hyun (National Development Institute of Korean Medicine) Park, Jeong-Eun (National Development Institute of Korean Medicine) Lim, Yu-Mi (National Development Institute of Korean Medicine) Kim, Eun-Jeong (National Development Institute of Korean Medicine) Son, Eun-Kyung (National Development Institute of Korean Medicine) Kim, Sang-Jun (Department of Natural Science, Republic of Korea Naval Academy) So, Jai-Hyun (National Development Institute of Korean Medicine) |
1 | Zeng W, Han H, Tao Y, Yang L, Wang Z, Chen K (2013) Identification of bio-active metabolites of gentiopicroside by UPLC/Q-TOF MS and NMR. Biomed Chroma 27: 1129-1136 DOI |
2 | Koseki T, Mese Y, Fushinobu S, Masaki K, Fujii T, Ito K, Iefuji H (2008) Biochemical characterization of a glycoside hydrolase family 61 endoglucanase from Aspergillus kawachii. Appl Micro Biotec 77: 1279-1285 DOI |
3 | Wojtunik-Kulesza KA, Oniszczuk A, Oniszczuk T, Waksmundzka-Hajnos M (2016) The influence of common free radicals and antioxidants on development of Alzheimer's Disease. Biomed Pharm 78: 39-49 DOI |
4 | Lee JY, Oh TH, Yune TY (2011) Ghrelin inhibits hydrogen peroxideinduced apoptotic cell death of oligodendrocytes via ERK and p38 MAPK signaling. Endoc 152: 2377-2386 DOI |
5 | Hao Y, Liu C, Huang J, Gu Y, Li H, Yang Z, Li R (2016) Ghrelin protects against depleted uranium-induced apoptosis of MC3T3-E1 cells through oxidative stress-mediated p38-mitogen-activated protein kinase pathway. Toxicol appl pharm 290: 116-125 DOI |
6 | Peng J, Lv YC, He PP, Tang YY, Xie W, Liu XY, Shi JF (2015) Betulinic acid down regulates expression of oxidative stress-induced lipoprotein lipase via the PKC/ERK/c-Fos pathway in RAW264. 7 macrophages. Bioch 119: 192-203 DOI |
7 |
Fu J, Shi Q, Song X, Xia X, Su C, Liu Z, Song Y (2016) Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/ |
8 | Wang Z, Wang C, Su T, Zhang J (2014) Antioxidant and immunological activities of polysaccharides from Gentiana scabra Bunge roots. Carbo Polym 112: 114-118 DOI |
9 | Kakuda R, Iijima T, Yaoita Y, Machida K, Kikuchi M (2002) Triterpenoids from Gentiana scabra. Phytochem 59: 791-794 DOI |
10 | Wang C, Wang Y, Zhang J, Wang Z (2014) Optimization for the extraction of polysaccharides from Gentiana scabra Bunge and their antioxidant in vitro and anti-tumor activity in vivo. J Tai Inst Chem Engineers 45: 1126-1132 DOI |
11 |
Riou C, Salmon JM, Vallier MJ, Gunata Z, Barre P (1998) Purification, characterization, and substrate specificity of a novel highly glucosetolerant |
12 | Kim JA, Son NS, Son JK, Jahng Y, Chang HW, Jang TS, Lee SH (2009) Two new secoiridoid glycosides from the rhizomes of Gentiana scabra Bunge. Arch Pharm Res 32: 863-867 DOI |
13 | Cai W, Xu H, Xie L, Sun J, Sun T, Wu X, Fu Q (2016) Purification, characterization and in vitro anticoagulant activity of polysaccharides from Gentiana scabra Bunge roots. Carbo Polym 140: 308-313 DOI |
14 | Palmerin-Carreno DM, Rutiaga-Quinones OM, Calvo JV, Prado-Barragan A, Huerta-Ochoa S (2015) Screening of microorganisms for bioconversion of (+)-valencene to (+)-nootkatone. LWT-Food Sci Tech 64: 788-793 DOI |
15 | Kan SC, Zang CZ, Yeh CW, Chang WF, Lin CC, Hung TH, Liu YC (2015) Enhanced bioconversion rate and released substrate inhibition in (R)-phenylephrine whole-cell bioconversion via partial acetone treatment. Enzy Microb Technol 86: 34-38 DOI |
16 | Yang EJ, Kim SI, Park SY, Bang HY, Jeong JH, So JH, Song KS (2012). Fermentation enhances the in vitro antioxidative effect of onion (Allium cepa) via an increase in quercetin content. Food Chem Toxicol 50: 2042-2048 DOI |
17 | Blois MS (1958) Antioxidant determination by the use of a stable free radical. Nature 26: 1198-1200 |
18 | Jabbari M, Jabbari A (2016) Antioxidant potential and DPPH radical scavenging kinetics of water-insoluble flavonoid naringenin in aqueous solution of micelles. Colloid Surf A: Physical Engineer Aspects 489: 392-399 DOI |
19 |
Zeng KW, Yu Q, Song FJ, Liao LX, Zhao MB, Dong X, Tu PF (2015) Deoxysappanone B, a homo isoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IeB kinase (IKK)-NF- |
20 |
Hu TY, Ju JM, Mo LH, Ma L, Hu WH, You RR, Chen XQ, Chen YY, Liu ZQ, Qiu LZ, Qiu SQ, Fan JT, Cheng BH (2019) Anti-inflammation action of xanthones from Swertia chirayita by regulating COX-2/NF- |
21 | Dannenberg AJ, Lippman SM, Mann JR, Subbaramaiah K, DuBois RN (2005) Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention. J Clin Oncol 23: 254-266 DOI |
22 | Lou H, Hu Y, Zhang L, Sun P, Lu H (2012) Nondestructive evaluation of the changes of total flavonoid, total phenols, ABTS and DPPH radical scavenging activities, and sugars during mulberry (Morus alba L.) fruits development by chlorophyll fluorescence and RGB intensity values. LWT-Food Sci Techno 47: 19-24 DOI |
23 | Kwaw E, Ma Y, Tchabo W, Apaliya MT, Wu M, Sacle Sackey A, Xiao L, Tahir HE (2018) Effect of lactobacillus strains on phenolic profile, color attributes and antioxidant activities of lactic -acid-fermented mulberry juice. Food Chem 250: 148-154 DOI |
24 |
Lai CS, Lee JH, Ho CT, Liu CB, Wang JM, Wang YJ, Pan MH (2009) Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX- 2 expression through down regulating MAPK, NF- |
25 | Nahar PP, Driscoll MV, Li L, Slitt AL, Seeram NP (2014) Phenolic mediated anti-inflammatory properties of a maple syrup extract in RAW 264.7 murine macrophages. J Func Foods 6: 126-136 DOI |
26 | Xiong H, Cheng Y, Zhang X, Zhang X (2014) Effects of taraxasterol on iNOS and COX-2 expression in LPS-induced RAW 264.7 macrophages. J Ethnopharm 155: 753-757 DOI |
27 | Lee J, Tae N, Lee JJ, Kim T, Lee JH (2010) Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264. 7 cells by inducing proteasomal degradation of TRAF6. Eur J Pharm 636: 173-180 DOI |
28 | Westermann D, Van Linthout S, Dhayat S, Dhayat N, Schmidt A, Noutsias M, Song XY, Spillmann F, Riad A, Schultheiss HP, Tschope C (2007) Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy. Basic Res Cardiol 102: 500-507 DOI |
29 | Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26: 1231-1237 DOI |
30 | Daabis RG, Rehem RNA, Hassan MM, Khalil GI (2016) Hypogonadism in patients with chronic obstructive pulmonary disease: relationship with airflow limitation, muscle weakness and systemic inflammation. Alexandria Univ Facul Med 52: 27-33 DOI |
31 | Dorward DA, Lucas CD, Rossi AG, Haslett C, Dhaliwal K (2012) Imaging inflammation: Molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution. Pharmacol Ther 135: 182-199 DOI |
32 | Li S, Wang Y, Zhao M, Wu J, Peng S (2015) BPIC: A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals. Bioorg Med Chem Lett 25: 1146-1150 DOI |
33 |
Wang F, Ma J, Wang KS, Mi C, Lee JJ, Jin X (2015) Blockade of TNF- |
34 | Vannini F, Kashfi K, Nath N (2015) The dual role of iNOS in cancer. Redox Biol 6: 334-343 DOI |
35 |
Zhang TZ, Yang SH, Yao JF, Du J, Yan TH (2015) Sangxingtang inhibits the inflammation of LPS-induced acute lung injury in mice by downregulating the MAPK/NF- |
36 | Maskrey BH, Megson IL, Whitfield PD, Rossi AG (2011) Mechanisms of resolution of inflammation a focus on cardiovascular disease. Arterioscler Thromb Vasc Biol 31: 1001-1006 DOI |
37 | Lepetsos P, Papavassiliou AG (2016) ROS/oxidative stress signaling in osteoarthritis. Biochim Biophy Acta 1862: 576-591 DOI |
38 | Yokota T, Wang Y (2016) p38 MAP kinases in the heart. Gene 575: 369-376 DOI |
39 | Park EJ, Shen L, Sun D, Pezzuto JM (2013) Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. J Nat Prod 77: 527-535 DOI |
40 |
Pasquali MAB, Gelain DP, Zeidan-Chuli F, Pires AS, Gasparotto J, Terra SR, Moreira JCF (2013) Vitamin A (retinol) down regulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF- |
41 |
Ma JQ, Li Z, Xie WR, Liu CM, Liu SS (1998) Quercetin protects mouse liver against CCl 4-induced inflammation by the TLR2/4 and MAPK/NF- |
42 | Lee JI, Burckart GJ (1998) Nuclear factor kappa B: important transcription factor and therapeutic target. J Clin Pharm 38: 981-993 DOI |
43 | Hsu CL, Fang SC, Liu CW, Chen YF (2013) Inhibitory effects of new varieties of bitter melon on lipopolysaccharide-stimulated inflammatory response in RAW 264.7 cells. J Func Food 5: 1829-1837 DOI |
44 |
Kim H, Youn K, Yun EY, Hwang JS, Jeong WS, Ho CT, Jun M (2015) Oleic acid ameliorates |
45 | Zo J, Feng D, Ling WH, Duan RD (2013) Lycopene suppresses proinflammatory response in lipopolysaccharide-stimulated macrophages by inhibiting ROS-induced trafficking of TLR4 to lipid raft-like domains. J Nutr Biochem 24: 1117-1122 DOI |
46 | Yang RL, Shi YH, Hao G, Li W, Le GW (2008) Increasing oxidative stress with progressive hyperlipidemia in human. J clin Biochem Nutr 43: 154-158 DOI |
47 | Zhou J, Xu G, Bai Z, Li K, Yan J, Li F, Ma S, Xu H, Huang K (2015) Selenite exacerbates hepatic insulin resistance in mouse model of type 2 diabetes through oxidative stress-mediated JNK pathway. Toxicol Appl Pharm 289: 409-418 DOI |
48 | Wang SW, Yang SG, Liu W, Zhang YX, Xu PX, Wang T, Liu RT (2016) Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease. Behav Brain Res 296: 109-117 DOI |
49 | Seo MJ, Lee YJ, Hwang JH, Kim KJ, Lee BY (2015) The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling. J Nutr Biochem 26: 1308-1316 DOI |
50 |
Park EJ, Cheenpracha S, Chang LC, Pezzuto JM (2011) Suppression of cyclooxygenase-2 and inducible NOS expression by epimuqubilin A via IKK/ |
51 | Wu KL, Chan SH, Chan JY (2012) Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation. J Neuroinfla 9: 1-15 DOI |
52 |
Liu D, Perkins JT, Hennig B (2016) EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF- |
53 |
Wann AKT, Chapple JP, Knight MM (2014) The primary cilium influences interleukin- |
54 | Heo SJ, Yoon WJ, Kim KN, Ahn GN, Kang SM, Kang DH, Affan A, Oh C, Jung WK, Jeon YJ (2010) Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharidestimulated RAW 264.7 macrophages. Food and Chem Toxi 48: 2045-2051 DOI |
55 | Floegel A, Kim DO, Chung SJ, Koo SI, Chun OK (2011) Comparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods. J Food Comp Analy 24: 1043-1048 DOI |
56 | Lafferty EI, Qureshi ST, Schnare M (2010) The role of toll-like receptors in acute and chronic lung inflammation. J Inflam 7: 1-14 DOI |
57 | Chesnokova V, Pechnick RN, Wawrowsky K (2016) Chronic peripheral inflammation, hippocampal neurogenesis, and behavior. Brain Behav Immun 58: 1-8 DOI |
58 | Singh A (2008) Phytochemicals of Gentianaceae: a review of pharmacological properties. Int J Pharma Sci Nanotec 1: 33-36 |
59 |
Karuppagounder V, Arumugam S, Thandavarayan RA, Pitchaimani V, Sreedhar R, Afrin R, Ueno K (2015) Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2- |
60 | Henrissat B, Bairoch A (1993) New families in the classification of glycosyl hydrolases based on amino acid sequence similarities. Biochem J 293: 781-788 DOI |
![]() |