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http://dx.doi.org/10.3839/jabc.2018.045

Anti-wrinkle efficacy of isoquercitrin isolated from Nymphoides indica  

Yu, Jae-Myo (Department of Korean Medicine Development, National Development Institute of Korean Medicine)
Kang, Yun-Hwan (Department of Korean Medicine Development, National Development Institute of Korean Medicine)
Kim, Dong-Hee (Department of Korean Medicine Development, National Development Institute of Korean Medicine)
Kim, You-Ah (Skin Science Research Institute, Kolmar Korea Co., Ltd.)
Kim, A-Hyun (Skin Science Research Institute, Kolmar Korea Co., Ltd.)
Park, Byoung-Jun (Skin Science Research Institute, Kolmar Korea Co., Ltd.)
Park, Tae-Soon (Department of Korean Medicine Development, National Development Institute of Korean Medicine)
Publication Information
Journal of Applied Biological Chemistry / v.61, no.4, 2018 , pp. 321-325 More about this Journal
Abstract
In this study, we evaluated the possibility of wrinkle-reducing functional cosmetic material of isoquercitrin (IQC) isolated from Nymphoides indica (NP) by measuring the efficacy of ROS inhibition, procollagen synthesis induction, and matrix metalloproteinase (MMP)-1 inhibition. As a result, ROS tended to be inhibited in a concentration dependent manner, and the procollagen protein synthesis rate was increased by 70% ($5{\mu}g/mL$) and the MMP-1 protein was decreased by 41% ($5{\mu}g/mL$) compared with the control. This was suggested the ability of IQC to induce the procollagen synthesis and to reduce the ROS and MMP-1 production. Therefore, it is considered that IQC isolated from NP has enough value to be a functional cosmetic material.
Keywords
Anti-oxidant; Anti-wrinkle; CCD-986sk; Elastase; Nymphoides indica; Procollagen;
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