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http://dx.doi.org/10.3839/jabc.2018.040

UV-induced skin damage improvement effects of solvent fraction from Maekmoondong-tang  

Yu, Jae-Myo (National Development Institute of Korean Medicine)
Kang, Yun-Hwan (National Development Institute of Korean Medicine)
Kim, Bo-Mi (National Development Institute of Korean Medicine)
Kim, Dong-Hee (National Development Institute of Korean Medicine)
Park, Tae-Soon (National Development Institute of Korean Medicine)
Publication Information
Journal of Applied Biological Chemistry / v.61, no.3, 2018 , pp. 283-290 More about this Journal
Abstract
In this study, we verified the 1-1-diphenyl-2-picryl-hydrazyl radical scavenge, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenge, elastase, tyrosinase inhibitory effect by using the solvent fractions of Maekmoondong-tang hot water extract. As a result, the ethyl acetate fraction (MW-EA) showed the highest inhibitory activity. In cell-based assays, MW-EA treatment confirmed a 34% ($100{\mu}g/mL$) efficacy in reactive oxygen species inhibitory activity, and at the same concentration, MMPs showed more than 50% inhibition and tyrosinase inhibited 25% ($50{\mu}g/mL$). Therefore Maekmoondong-tang is considered high development potential as a material to improve the skin.
Keywords
Anti-oxidant; Anti-wrinkle; CCD-986sk; HEM; Maekmoondong-tang; Whitening;
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Times Cited By KSCI : 8  (Citation Analysis)
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