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http://dx.doi.org/10.3839/jabc.2018.033

Simultaneous determination of methoxyflavones in selected Korean thistles  

Rodriguez, Joyce P. (Department of Integrative Plant Science, Chung-Ang University)
Quilantang, Norman G. (Department of Integrative Plant Science, Chung-Ang University)
Lee, Ju Sung (Department of Integrative Plant Science, Chung-Ang University)
Park, Jun Yeon (Department of Food Science and Biotechnology, Kyonggi University)
Shim, Jae Suk (Imsil Herbal Medicine Association)
Kang, Ki Sung (College of Korean Medicine, Gachon University)
Cho, Eun Ju (Department of Food Science and Nutrition, Pusan National University)
Geraldino, Paul John L. (Department of Biology, University of San Carlos)
Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University)
Publication Information
Journal of Applied Biological Chemistry / v.61, no.3, 2018 , pp. 227-232 More about this Journal
Abstract
Simultaneous determination of three methoxyflavones, namely, cirsimarin (1), hispidulin (2), and cirsimaritin (3) in selected Korean thistles was performed via reversed-phase high performance liquid chromatography system. Compound 1 was present in all the thistle species examined, whereas 2 and 3 were only detected in Cirsium japonicum and C. japonicum var. maackii (CJM). The concentration of compounds 1-3 in CJM varied according to the time of harvest. Plants collected in the spring (CJMS) and fall (CJMF) had the highest contents of 3 and 1, respectively. A lower content of 2 was observed in CJMF than in CJMS. This indicates that seasonal variation affects the flavonoid content of CJM. The results of this study show that CJM is an excellent source of compounds 1-3 and it can potentially be cultivated for industrial and pharmaceutical applications involving these compounds.
Keywords
Cirsimarin; Cirsimaritin; High performance liquid chromatography-UV; Hispidulin; Korean thistles; Methoxyflavone;
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1 Rodriguez J, Lee YK, Woo DG, Shim JS, Geraldino PJ, Jacinto S, Lee S (2018) Flavonoids from Cirsium japonicum var. maackii pappus as inhibitors of aldose reductase and their simultaneous determination. Chem Pap 72: 81-88   DOI
2 Jeong DM, Jung HA, Choi JS (2008) Comparative antioxidant activity and HPLC profiles of some selected Korean thistles. Arch Pharm Res 31: 28-33   DOI
3 Ishida H, Umino T, Tsuji K, Kosuge T (1987) Studies on antihemorrhagic substances in herbs classified as hemostatics in Chinese medicine. VII on the antihemorrhagic principle in Cirsium japonicum DC.Chem Pharm Bull 35: 861-864   DOI
4 Ganzera M, Pocher A, Stuppner H (2005) Differentiation of Cirsium japonicum and C. setosum by TLC and HPLC-MS. Phytochem Anal 16: 205-209   DOI
5 Morita N, Shimizu M, Arisawa M (1973) Two new flavone glycosides from Cirsium lineare. Phytochemistry 12: 421-423   DOI
6 Park JC, Lee JH, Choi JS (1995) A flavone diglycoside from Cirsium japonicum var. ussuriense. Phytochemistry 39: 261-262   DOI
7 Lee WB, Kwon HC, Cho OR, Lee KC, Choi SU, Baek NI, Lee KR (2002) Phytochemical constituents of Cirsium setidens Nakai and their cytotoxicity against human cancer cell lines. Arch Pharm Res 25: 628-635   DOI
8 Zhang Q, Tu G, Zhao Y, Cheng T (2002) Novel bioactive isoquinoline alkaloids from Carduus crispus. Tetrahedron 58: 6795-6798   DOI
9 Yoo YM, Nam JH, Kim MY, Choi JW, Park HJ (2008) Pectolinarin and pectolinarigenin of Cirsium setidens prevent the hepatic injury in rats caused by D-galagtosamine via an antioxidant mechanism. Biol Pharm Bull 31: 760-764   DOI
10 Liu S, Luo X, Li D, Zhang J, Qiu D, Liu W, She L, Yang Z (2006) Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int J Immunopharmacol 6: 1387-1393   DOI
11 Han JY, Ahn SY, Kim CS, Yoo SK, Kim SK, Kim HC, Hong JT, Oh KW (2012) Protection of apigenin against kainite-induced excitotoxicity by anti-oxidative effects. Biol Pharm Bull 35: 1440-1446   DOI
12 Jin SE, Min BS, Kim BW, Choi JS (2012) Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin-5-Oglucoside. Food Chem Toxicol 50: 2171-2179   DOI
13 Quan Z, Gu J, Dong P, Lu J, Wu X, Wu W, Fei X, Li S, Wang Y, Wang J, Liu Y (2010) Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimarininduced apoptosis in human gallbladder carcinoma. Cancer Lett 295:252-259   DOI
14 Chung MJ, Lee S, Park YI, Lee JS, Kwon KH (2016) Neuroprotective effects of phytosterols and flavonoids from Cirsium setidens and Aster scaber in human brain neuroblastoma SK-N-SH cells. Life Sci 148: 173-182   DOI
15 Lee J, Rodriguez J, Lee KH, Park JY, Kang KS, Hahm DH, Huh CK, Lee SC, Lee S (2017) Determination of flavonoids from Cirsium japonicum var. maackii and their inhibitory activities against aldose reductase. Appl Biol Chem 60: 487-496   DOI
16 Rodriguez J, Lee J, Park JY, Kang KS, Hahm DH, Lee SC, Lee S (2017) HPLC-UV analysis of sample preparation influence on flavonoid yield from Cirsium japonicum var. maackii. Appl Biol Chem 60: 519-525   DOI
17 Hasrat JA, De Bruyne T, De Backer JP, Vauquelin G, Vlietinck A (1997) Cirsimarin and cirsimaritin, flavonoids of Microtea debilis (Phytolaccaceae) with adenosine antagonistic properties in rats: leads for new therapeutics in acute renal failure. J Pharm Pharmacol 49: 1150-1156   DOI
18 Kavvadias D, Sand P, Youdim K, Qaiser Z, Rice-Evans C, Baur R, Sigel E, Rausch WD, Riederer P, Schreir P (2004) The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br J Pharmacol 142: 811-820   DOI
19 Park JY, Yun H, Jo J, Baek JY, Lee SC, Choi YJ, Shim JS, Choi HJ, Lee S, Kang KS (2018) Beneficial effects of Cirsium japonicum var. maackii on menopausal symptoms in ovariectomized rats. Food Funct 9: 2480-2489   DOI