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http://dx.doi.org/10.3839/jabc.2018.026

The protective effect of berberine on Propionibacterium acnes-induced inflammatory response in human monocytes  

Kim, Hyun Pyo (Department of Biomedical Science, Jungwon University)
Yoon, Young Geol (Department of Biomedical Science, Jungwon University)
Publication Information
Journal of Applied Biological Chemistry / v.61, no.2, 2018 , pp. 181-186 More about this Journal
Abstract
In this study, we investigated the anti-inflammatory activity of berberine using human monocytes. Infection of Propionibacterium acnes induced the production of nitric oxide (NO) and the pro-inflammatory cytokines such as, $TNF-{\alpha}$, IL-8 and $IL-1{\beta}$ in THP-1 monocytic cells. However, when berberine was supplemented in these P. acnes-induced THP-1 cells, the production of pro-inflammatory cytokines and NO was significantly reduced. We also analyzed signaling pathways of the antiinflammatory function of berberine and found that berberine suppressed the phosphorylation of ERK1/2, JNK and p38 and the expression and nuclear translocation of $NF-{\kappa}B$ p65 in the P. acnes-induced cells. From these results, we concluded that berberine can effectively exert the anti-inflammatory activity via suppressing the $NF-{\kappa}B$ and mitogen-activated protein kinases signaling pathways in human monocytes. Moreover, these results suggest the feasibility of developing natural therapeutics using berberine for the treatment of P. acnes-induced inflammatory diseases.
Keywords
Berberine; Inflammation; Monocytes; Pro-inflammatory cytokines; Propionibacterium acnes;
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