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http://dx.doi.org/10.3839/jabc.2017.006

Aldose reductase inhibitory activity of quercetin from the stems of Rhododendron mucronulatum for. albiflorum  

Lee, Jaemin (Department of Integrative Plant Science, Chung-Ang University)
Ryu, Hyun-Sung (Pyeongtaek High School)
Rodriguez, Joyce P. (Department of Integrative Plant Science, Chung-Ang University)
Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University)
Publication Information
Journal of Applied Biological Chemistry / v.60, no.1, 2017 , pp. 29-33 More about this Journal
Abstract
The methanol extract of Rhododendron mucronulatum for. albiflorum (RMFA) stems inhibited aldose reductase (AR) activity. The RMFA fractions obtained by stepwise extraction with solvents of different polarity were tested for AR inhibition in vitro using the lens of a rat. Among them, the ethyl acetate (EtOAc) fraction inhibited AR more than the other fractions. Quercetin (1) from the EtOAc fraction showed a high AR inhibition with $IC_{50}$ of $2.11{\mu}M$. The stems of RMFA contained the highest amount (5.12 mg/g extract) of quercetin. Our results suggest that RMFA, which contained quercetin, could be a useful material for the development of supplementary functional foods.
Keywords
Aldose reductase inhibition; High-performance liquid chromatography; Quercetin; Rhododendron mucronulatum for.albiflorum;
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Times Cited By KSCI : 2  (Citation Analysis)
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