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http://dx.doi.org/10.3839/jabc.2017.005

Anti-obesity effect of Amomum taso-ko ethanol extract in 3T3-L1 adipocytes  

Lee, Jung A (Bio-center, Gyeonggido Business and Science Accelerator)
Park, Young Jin (Bio-center, Gyeonggido Business and Science Accelerator)
Jeong, Wonsik (Bio-center, Gyeonggido Business and Science Accelerator)
Hong, Seong Su (Bio-center, Gyeonggido Business and Science Accelerator)
Ahn, Eun-Kyung (Bio-center, Gyeonggido Business and Science Accelerator)
Publication Information
Journal of Applied Biological Chemistry / v.60, no.1, 2017 , pp. 23-28 More about this Journal
Abstract
Amomum tsao-ko used as a traditional oriental herbal medicine, is indigenous to several Asia countries. In this study, we investigated anti-obesity activity of the ethanol extract of Amomum Taso-ko (A. tsao-ko). The ethanol extract of A. tsao-ko inhibited adipocyte differentiation using Oil Red O assay in 3T3-L1 cells. Inhibitory effect of the ethanol extract of A. tsao-ko on adipogenesis was modulated by down-regulation adipogenic transcriptional factor such as peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), CCAAT-enhancer-binding protein ${\alpha}$ ($C/EBP{\alpha}$) and suppressed expression of fatty acid synthase, aP2, and resistin. We demonstrated that A. tsao-ko significantly inhibited adipogenesis and reduced $PPAR{\gamma}$ and $C/EBP{\alpha}$ expression in a dose-dependent manner. These results suggest that A. tsao-ko has an anti-obesity effect by inhibition of adipogenic transcription factor and adipocyte-specific genes in 3T3-L1 cells.
Keywords
Adipogenesis; Amomum tsao-ko; CCAAT-enhancer-binding protein ${\alpha}$; Peroxisome proliferator-activated receptor ${\gamma}$; 3T3-L1;
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