Browse > Article
http://dx.doi.org/10.3839/jabc.2016.026

Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle  

Pak, Pyo June (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
Go, Eun Byeol (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
Hwang, Min Hee (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
Lee, Dong Gun (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
Cho, Mi Ju (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
Joo, Yong Hoon (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
Chung, Namhyun (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
Publication Information
Journal of Applied Biological Chemistry / v.59, no.2, 2016 , pp. 145-147 More about this Journal
Abstract
Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anti-cancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.
Keywords
Citrate synthesis; Drug delivery system; Gold nanoparticle; Quercetin;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Harris PE, Cooper KL, Relton C, Thomas KJ (2012) Prevalence of complementary and alternative medicine (CAM) use by the general population: a systematic review and update. Int J Clin Pract 66: 924-939   DOI
2 Jung HJ, Pak PJ, Park SH, Ju JE, Kim JS, Lee HS, Chung N (2014) Silver wire amplifies the signaling mechanism for IL-1beta production more than silver submicroparticles in human monocytic THP-1 cells. PLoS One 9: e112256   DOI
3 Kim BI, Joo YH, Pak PJ, Kim JS, Chung N (2015) Different shapes of $Al_2O_3$ particles induce differential cytotoxicity via a mechanism involving lysosomal destabilization and reactive oxygen species generation. J Korean Soc Appl Biol Chem 58: 433-442   DOI
4 Kumar A, Zhang X, Liang XJ (2013) Gold nanoparticles: emerging paradigm for targeted drug delivery system. Biotechnol Adv 31: 593-606   DOI
5 Loganayaki N, Siddhuraju P, Manian S (2012) Antioxidant, anti-inflammatory and anti-nociceptive effects of Ammannia baccifera L. (Lythracceae), a folklore medicinal plant. J Ethnopharmacol 140: 230-233   DOI
6 Pal R, Panigrahi S, Bhattacharyya D, Chakraborti AS (2013) Characterization of citrate capped gold nanoparticle-quercetin complex: Experimental and quantum chemical approach. J Mol Struct 1046: 153-163   DOI
7 Rubio L, Motilva MJ, Romero MP (2013) Recent advances in biologically active compounds in herbs and spices: a review of the most effective antioxidant and anti-inflammatory active principles. Crit Rev Food Sci Nutr 53: 943-953   DOI
8 Russo GL, Russo M, Spagnuolo C, Tedesco I, Bilotto S, Iannitti R, Palumbo R (2014) Quercetin: a pleiotropic kinase inhibitor against cancer. Cancer Treat Res 159: 185-205   DOI
9 Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL (2012) The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol 83: 6-15   DOI
10 Sidhu MC, Sharma T (2013) Medicinal plants from twelve families having antidiabetic activity: a review. Am J PharmTech Res 3: 36-52
11 Verma HN, Singh P, Chavan RM (2014) Gold nanoparticle: synthesis and characterization. Vet World 7: 72-77   DOI
12 Wang J, Zhou ND, Zhu ZQ, Huang JY, Li GX (2007) Detection of flavonoids and assay for their antioxidant activity based on enlargement of gold nanoparticles. Anal Bioanal Chem 388: 1199-1205   DOI