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http://dx.doi.org/10.3839/jabc.2016.009

Some Monascus purpureus Genomes Lack the Monacolin K Biosynthesis Locus  

Kwon, Hyung-Jin (Department of Biological Science and Bioinformatics, Myongji University)
Balakrishnan, Bijinu (Department of Biological Science and Bioinformatics, Myongji University)
Kim, Yeon-Ki (Department of Biological Science and Bioinformatics, Myongji University)
Publication Information
Journal of Applied Biological Chemistry / v.59, no.1, 2016 , pp. 45-47 More about this Journal
Abstract
Two Monascus purpureus genomes lack the monacolin K biosynthesis locus (mok), while Monascus species are generally assumed to be monacolin K producers. These M. purpureus harbor a fusion of mokA and mokB orthologues. This finding suggests that an ancestral mok locus underwent a deletion event in the M. purpureus genome.
Keywords
genome sequence; monacolin K biosynthetic gene cluster; Monascus purpureus; polyketide synthase gene;
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1 Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25, 3389-402.   DOI
2 Balakrishnan B, Chen CC, Pan TM, and Kwon HJ (2014) Mpp7 controls regioselective Knoevenagel condensation during the biosynthesis of Monascus azaphilone pigments. Tetrahedron Lett 55, 1640-3.   DOI
3 Balakrishnan B, Karki S, Chiu SH, Kim HJ, Suh JW, Nam B et al. (2013) Genetic localization and in vivo characterization of a Monascus azaphilone pigment biosynthetic gene cluster. Appl Microbiol Biotechnol 97, 6337-45.   DOI
4 Chen YP, Tseng CP, Chien IL, Wang WY, Liaw LL, and Yuan GF (2008a) Exploring the distribution of citrinin biosynthesis related genes among Monascus species. J Agric Food Chem 56, 11767-72.   DOI
5 Chen YP, Tseng CP, Liaw LL, Wang CL, Chen IC, Wu WJ et al. (2008b) Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus. J Agric Food Chem 56, 5639-46.   DOI
6 Feng Y, Shao Y, and Chen F (2012) Monascus pigments. Appl Micorbiol Biotechnol 96, 1421-40.   DOI
7 Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, and Hutchinson CR (1999) Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 284, 1368-72.   DOI
8 Lee CL and Pan TM (2012) Development of Monascus fermentation technology for high hypolipidemic effect. Appl Microbiol Biotechnol 94, 1449-59.   DOI
9 Li YG, Zhang F, Wang ZT, and Hu ZB (2004) Identification and chemical profiling of monacolins in red yeast rice using high-performance liquid chromatography with photodiode array detector and mass spectrometry. J Pharm Biomed Anal 35, 1101-12.   DOI
10 Liu Q, Xie N, He Y, Wang L, Shao Y, Zhao H et al. (2014) MpigE, a gene involved in pigment biosynthesis in Monascus ruber M7. Appl Microbiol Biotechnol 98, 285-96.   DOI
11 Marchler-Bauer A, Derbyshire MK, Gonzales NR, Lu S, Chitsaz F, Geer LY et al. (2015) CDD: NCBI's conserved domain database. Nucleic Acids Res 43, D222-6.   DOI
12 Patakova P (2013) Monascus secondary metabolites: production and biological activity. J Ind Microbiol Biotechnol 40, 169-81.   DOI
13 Sakai K, Kinoshita H, Shimizu T, and Nihira T (2008) Construction of a citrinin gene cluster expression system in heterologous Aspergillus oryzae. J Biosci Bioeng 106, 466-72.   DOI
14 Shimizu T, Kinoshita H, and Nihira T (2007) Identification and in vivo functional analysis by gene disruption of ctnA, an activator gene involved in citrinin biosynthesis in Monascus purpureus. Appl Environ Microbiol 73, 5097-103.   DOI
15 Wang TH and Lin TF (2007) Monascus rice products. Adv Food Nutr Res 53, 123-59.   DOI
16 Yang Y, Liu B, Du X, Li P, Liang B, Cheng X et al. (2015) Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1. Sci Rep 5:8331.   DOI
17 Yasuda M, Tachibana S, and Kuba-Miyara M (2012) Biochemical aspects of red koji and tofuyo prepared using Monascus fungi. Appl Microbiol Biotechnol 96, 49−60.   DOI