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http://dx.doi.org/10.3839/jabc.2015.052

Whitening Effect of Salvia miltorrhiza Bunge Water Extract in Human Epidermal Melanocyte  

Park, Tae-Soon (Korea Promotion Institute for Traditional Medicine Industry)
Kim, Dong-Hee (Korea Promotion Institute for Traditional Medicine Industry)
Son, Jun-Ho (Korea Promotion Institute for Traditional Medicine Industry)
Publication Information
Journal of Applied Biological Chemistry / v.58, no.4, 2015 , pp. 333-338 More about this Journal
Abstract
The objective of this study was to investigate the whitening effect of Salvia miltorrhiza Bunge water extract (SM-W) in human epidermal melanocyte (HEM). Mushroom tyrosinase inhibitory effect of SM-W was approximately 42% at $1,000{\mu}g/mL$. The HEM cellular tyrosinase and melanin synthesis inhibition activity were 26 and 25% at $5{\mu}g/mL$, respectively. Whitening related proteins and mRNAs including tyrosinase, tyrosinase related protein 1 (TRP-1) and TRP-2, and microphthalmia associated transcription factor were reduced by SM-W treatment. In addition, the cAMP expression inhibitory effect of SM-W was decreased by 41% at $5{\mu}g/mL$ concentration. These results indicated that Salvia miltorrhiza Bunge could be used to the possible utilization of functional cosmetic ingredients by confirming whitening activity related with melanin content.
Keywords
cosmetic; human epidermal melanocyte; Salvia miltorrhiza Bunge; tyrosinase; whitening;
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Times Cited By KSCI : 3  (Citation Analysis)
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