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http://dx.doi.org/10.3839/jabc.2014.029

Methanol Extract of Alpinia katsumadai Hayata has Anti-viral Activity by Inhibition of α-glucosidase  

Lee, Doseung (Jeju Biodiversity Research Institute (JBRI), Jeju Technopark)
Boo, Kyung Hwan (Subtropical Horticulture Research Institute, Jeju National University)
Kim, Young Cheon (Subtropical Horticulture Research Institute, Jeju National University)
Lee, Jin-Man (Department of Food & Biotechnology, Hoseo University)
Kim, Seong Cheol (Agricultural Research Center for Climate Change, National Institute of Horticultural & Herbal Science, Rural Development Administration)
Lee, Wang Shik (College of Applied Life Science(SARI), Jeju National University, Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University)
Riu, Key Zung (College of Applied Life Science(SARI), Jeju National University, Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University)
Lee, Dong-Sun (College of Applied Life Science(SARI), Jeju National University, Research Institute for Subtropical Agriculture and Biotechnology, Jeju National University)
Publication Information
Journal of Applied Biological Chemistry / v.57, no.2, 2014 , pp. 179-182 More about this Journal
Abstract
In the present study, we investigated the effects of methanol extracts from Alpinia katsumadai Hayata against antiviral potential underlying mechanism in glucosidase inhibition. Syncytium formation in Newcastle disease virus (NDV)-infected baby hamster kidney (BHK) cell originates from the trafficking of viral glycoprotein into cell-surface. Methanol extracts inhibited not only syncytium formation, but also trafficking of glycoprotein, hemagglutinin-neuraminidase (HN), onto cell-surface. A. katsumadai extracts showed the inhibitory activities ($IC_{50}$ $25{\mu}g/mL$) against ${\alpha}$-glucosidase. These results suggested that blue chanterelle extracts inhibited the cell-surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.
Keywords
${\alpha}$-glucosidase inhibition; antiviral activities; methanol extract of Alpinia katsumadai;
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