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http://dx.doi.org/10.3839/jabc.2013.028

Cytotoxicity of Neolignans from Magnolia obovata Fruits  

Seo, Kyeong-Hwa (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University)
Lee, Dae-Young (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Jeong, Rak-Hun (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University)
Yoo, Ki-Hyun (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University)
Chung, In-Sik (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University)
Kim, Geum-Soog (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Seo, Woo-Duck (Department of Functional Crop, National Institute of Crop Science, RDA)
Kang, Hee-Cheol (GFC Co., Ltd.)
Ahn, Eun-Mi (Department of Herbal Foodceutical Science, Daegu Haany University)
Baek, Nam-In (Graduate School of Biotechnology and Department of Oriental Medicinal Materials & Processing, Kyung Hee University)
Publication Information
Journal of Applied Biological Chemistry / v.56, no.3, 2013 , pp. 179-181 More about this Journal
Abstract
Repeated $SiO_2$ and octadecyl silica gel (ODS) column chromatographies of the EtOAc fraction from Magnolia obovata fruits, 10 neolignans, named magnolol (1), honokiol (2), isoobovatol (3), isomagnolol (4), obovatol (5), obovatal (6), 9-methoxyobovatol (7), magnobovatol (8), obovaaldehyde (9), and 2-hydroxyobovaaldehyde (10) were isolated and identified. All isolated compounds were evaluated for in vitro cytotoxicity against seven human cancer cell lines.
Keywords
cancer cell; cytotoxicity; honokiol; Magnolia obovata; magnolol; neolignan;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
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