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http://dx.doi.org/10.3839/jabc.2012.035

Anti-inflammatory Activity of the Undaria pinnatifida Water Extract  

Jeong, Da-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Kim, Koth-Bong-Woo-Ri (Institute of Fisheries Sciences/Pukyong National University)
Kang, Bo-Kyeong (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Jung, Seul-A (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Kim, Hyun-Jee (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Jeong, Hee-Ye (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Bark, Si-Woo (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Ahn, Dong-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Publication Information
Journal of Applied Biological Chemistry / v.55, no.4, 2012 , pp. 221-225 More about this Journal
Abstract
The anti-inflammatory effects of Undaria pinnatifida water extract (UPWE) were investigated using lipopolysaccharide-induced inflammatory response in this study. To examine the potential anti-inflammatory properties of UPWE, the cell proliferation, nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-${\alpha}$) and IL-$1{\beta}$ were measured. As a result, there was no cytotoxicity in the macrophage proliferation treated with UPWE compared to the control. NO levels decreased with increasing concentration of UPWE. Moreover, the secretion of IL-6, TNF-${\alpha}$ and IL-$1{\beta}$ were suppressed in a dose-dependent manner, and IL-6 inhibition activities were over 50% at 0.1%. These results suggested that UPWE may have significant effects on inflammatory factors and be a potential anti-inflammatory therapeutic materials.
Keywords
anti-inflammatory; cytokines; Undaria pinnatifida;
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Times Cited By KSCI : 12  (Citation Analysis)
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