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http://dx.doi.org/10.3839/jabc.2012.026

Antibacterial Activity of Triterpenoids from Clerodendron trichotomum  

Choi, Ji Won (Department of Food Science and Nutrition, Pusan National University)
Cho, Eun Ju (Department of Food Science and Nutrition, Pusan National University)
Lee, Dong Gu (Department of Integrative Plant Science, Chung-Ang University)
Choi, Kyung (Department of Forest Resource Conservation, Korea National Arboretum)
Ku, Jajung (Department of Forest Resource Conservation, Korea National Arboretum)
Park, Kwang-Woo (Department of Forest Resource Conservation, Korea National Arboretum)
Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University)
Publication Information
Journal of Applied Biological Chemistry / v.55, no.3, 2012 , pp. 169-172 More about this Journal
Abstract
The aim of this research was to investigate the antibacterial activity of Clerodendron trichotomum. Antibacterial activities of the n-hexane, methylene chloride (MC), ethyl acetate, and n-butanol fractions from C. trichotomum were tested against Staphylococcus aureus, Escherichia coli, and Helicobacter pylori. The n-hexane and MC fractions showed antibacterial activity against H. pylori at a concentration of 1.7 mg/mL and showed inhibition zones of 10 and 11 mm in disc assay, respectively. Further testing of 22-dehydroclerosterol and ${\beta}$-amyrin (each 3.4 mg/mL) from the MC fraction of C. trichotomum revealed moderate antibacterial effects against E. coli, S. aureus, and H. pylori. In particular, ${\beta}$-amyrin showed clear zones of 12 and 13 mm against E. coli and H. pylori, respectively, suggesting its potential as an antibacterial agent. The active compounds from C. trichotomum might provide a promising therapeutic agent against infections by E. coli, S. aureus, and H. pylori.
Keywords
antibacterial activity; ${\beta}$-amyrin; Clerodendron trichotomum; 22-dehydroclerosterol;
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