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http://dx.doi.org/10.3839/jabc.2011.064

Dietary Effects of Post-fermented Green Tea by Monascus pilosus on the Body Weight, Serum Lipid Profiles and the Activities of Hepatic Antioxidative Enzymes in Mouse Fed a High Fat Diet  

Lee, Sang-Il (Department of Food, Nutrition and Cookery, Keimyung College)
Lee, Ye-Kyung (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University)
Kim, Soon-Dong (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University)
Yang, Seung-Hwan (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University)
Suh, Joo-Won (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University)
Publication Information
Journal of Applied Biological Chemistry / v.55, no.2, 2012 , pp. 85-94 More about this Journal
Abstract
The anti-obese, hypolipidemic and hepatoprotective effects of post-fermented green tea by Monascus pilosus was tested with mice fed with high-fat diet for 7 weeks. The body weight gain and feed efficiency ratio (FER) in normal control group (NC), CHA (2% non-fermented green tea powder supplemented high-fat diet group) and mCHA (2% green tea powder post-fermented by M. pilosus supplemented high fat diet group) groups were significantly lower than those of high fat diet control group (HC). Epididymal fat weight in mCHA and NC were significantly lower than HC. The hepatic lipid peroxide was dramatically higher in HC than that of NC and was significantly lower in CHA and mCHA. In addition, dehydrogenase type activity of xanthine oxidoreductase in HC was lower than that of NC, but significantly higher than CHA and mCHA. In histopathological findings, hepatic fat accumulation in HC was higher than that of NC, CHA and mCHA. Antiobese, hypolipidemic and antifatty liver effect of green tea powder post-fermented by M. pilosus was slightly higher than that of non-fermented green tea. In conclusion, the constituents of green tea fermented by M. pilosus has been proven to not only inhibit obesity and hyperlipidemia but also decrease the hepatic fat accumulation in high fat diet-induced obese mice.
Keywords
anti-fatty liver; antiobese; antioxidative enzymes; hypolipidemic; Monascus pilosus; post-fermented tea;
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