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http://dx.doi.org/10.3839/jabc.2011.057

Effects of Arabinoxylan Rice Bran and Exercise Training on Immune Function and Inflammation Response in Lipopolysaccharide-stimulated Rats  

Son, Hee-Jeong (Exercise Physiology, Korea National Sport University)
Kim, Hyung-Jun (Exercise Physiology, Korea National Sport University)
Chae, Jeong-Hoon (Physiology, Eulji University of School of Medicine)
Kwon, Hyung-Tae (Exercise Physiology, Korea National Sport University)
Yeo, Hyo-Seong (Exercise Physiology, Korea National Sport University)
Eo, Su-Ju (Exercise Physiology, Korea National Sport University)
Leem, Yea-Hyun (Asan Institute for Life Sciences, Asan Medical Center)
Kim, Hyo-Jeong (Exercise Physiology, Korea National Sport University)
Kim, Chang-Keun (Exercise Physiology, Korea National Sport University)
Publication Information
Journal of Applied Biological Chemistry / v.55, no.1, 2012 , pp. 41-46 More about this Journal
Abstract
Arabinoxylan (Ara) rice bran has been shown to be a potent biological response modifier as manifested by stimulation of different arms of the immune system. We examined the effects of Ara rice bran and exercise on the immune function and cytokines in lipopolysaccharide (LPS)-stimulated rats. As the results, tumor necrosis factor-${\alpha}$ as representative inflammatory cytokines showed a significantly lower in Ara supplement group, thus the Ara rice bran had a higher inhibitory activity than the both exercise and control group. However, 4 weeks of exercise training significantly increased inflammatory reactions rather than treatment with Ara in LPS-treated rats. The Ara rice bran acted to decrease the inflammatory reaction. These results suggest that the supplement of Ara rice bran is likely contribute to inflammation response and the Ara rice bran can be used as a possible safe alternative to the immunotherapeutic modalities.
Keywords
arabinoxylan rice bran; immune function; inflammatory cytokines;
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