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http://dx.doi.org/10.3839/jabc.2011.046

Whitening Activities of the Agrimonia pilosa L. Extracts  

Kim, Dong-Hee (Daegu Gyeongbuk Institute for Oriental Medicine Industry)
An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
Lee, Jin-Young (Department of Herbal Cosmetic Science, Hoseo University)
Publication Information
Journal of Applied Biological Chemistry / v.54, no.4, 2011 , pp. 284-289 More about this Journal
Abstract
The extracts of Agrimonia pilosa L. were investigated for the inhibitory effect on the melanin synthesis in B16/F10 mouse melanoma cells as a functional ingredient for cosmetic products. Tyrosinase inhibition activities were 42% in A. pilosa L. 70% ethanol extract at $500{\mu}g/mL$. The protein and mRNA expression of tyrosinase, which are all skin-whitening related factors, showed that A. pilosa L. water and A. pilosa L. 70% ethanol extracts inhibited the protein bio-synthesis in B16F10 melanoma cell. Results indicate that the A. pilosa L. extracts tested in the present study have skin whitening activity and can be used as a functional ingredient for cosmetic compositions.
Keywords
Agrimonia pilosa L.; inhibition of melanin synthesis; mRNA; tyrosinase; tyrosinase protein;
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Times Cited By KSCI : 5  (Citation Analysis)
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