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http://dx.doi.org/10.3839/jabc.2011.044

Moderating Effects of Skin Hyperpigmentation from Lycii fructus and Lycii folium Extracts  

Kim, Dong-Hee (Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Lee, Soo-Yeon (Department of Herbal Cosmetic Science, Hoseo University)
Kim, Nam-Kyung (Bokja Girl's High School)
Youn, Bo-Kyung (Bokja Girl's High School)
Jung, Da-Som (Bokja Girl's High School)
Choi, Eun-Young (Bokja Girl's High School)
Hong, So-Ri (Bokja Girl's High School)
Yoon, Ji-Young (Department of Herbal Cosmetic Science, Hoseo University)
Kang, Myung-Hwa (Department of Food Science & Nutrition, Hoseo University)
Lee, Jin-Young (Department of Herbal Cosmetic Science, Hoseo University)
Publication Information
Journal of Applied Biological Chemistry / v.54, no.4, 2011 , pp. 270-278 More about this Journal
Abstract
The objective of the present study was to evaluate the skin whitening effect of the extracts, Lycii fructus (LF), Dry-L. foilum (DLF) and Fresh-L. folium (FLF). Tyrosinase inhibition activities was 44% in DLF ethanol extracts at a $500{\mu}g/mL$. When the tyrosinase activities in B16F10 murine melanoma cell were tested, the activities in DLF ethanol extracts was 14% at a $50{\mu}g/mL$ concentration. The protein expression of microphthalmia-associated transcription factor, tyrosinase related protein 1 (TRP-1), TRP-2, and tyrosinase, which are all melanin related factors, showed that LF, DLF and FLF extracts inhibited the protein bio-synthesis in B16F10 melanoma cell. Especially the DLF extract showed greater decrease of protein expressions. Results indicate that the DLF extract tested in the present study had skin whitening activity and can be used as a function a ingredients for food and cosmetic compositions.
Keywords
Dry-Lycii foilum; Fresh-L. folium; Lycii fructus; microphthalmia-associated transcription factor; tyrosinase related protein 1 (TRP-1); TRP-2; tyrosinase;
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Times Cited By KSCI : 7  (Citation Analysis)
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