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http://dx.doi.org/10.3839/jabc.2010.020

Synthesis of Salens and Their Cobalt Complexes from Meso-1,2-Diamine and Their Anti-Cancer Property  

Koh, Dong-Soo (Department of Applied Chemistry, Dongduk Women's University)
Publication Information
Journal of Applied Biological Chemistry / v.53, no.2, 2010 , pp. 108-111 More about this Journal
Abstract
New salens (3) and their Cobalt complexes (4) were prepared from meso-1,2-bis(ortho-hydroxyphenyl)-1,2-diaminoethane (1) and substituted salicylic aldehydes (2). In contrast to symmetric structure of salen ligand (3), salen-Co(III) complexes (4) showed dissymmetric molecular structure due to participation of three hydroxyl groups in complex formation. One of the salens (3b) revealed decrease in Cyclin D1 expression, which represents anti-cancer property.
Keywords
Cobalt complex; CyclinD1; hydrogen bond; imines; salens;
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