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http://dx.doi.org/10.3839/jabc.2010.003

Anti-oxidant and Anti-microbial Activities of Seungmakalgeuntang  

Lee, Jin-Young (Department of Herbal Cosmetic Science, Hoseo University)
Bae, Ho-Jung (Department of Cosmeceutical Science, Daegu Haany University)
Park, Tae-Soon (R&D Hanbang Cosmetic Team, Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Kim, Tae-Wan (Department of Food Science & Biotechnology, Andong National University)
Moon, Doo-Hwan (PioKorea Co., LTD.)
Kwon, O-Jun (Gyeongbuk Regional Innovation Agency)
Son, Jun-Ho (R&D Hanbang Cosmetic Team, Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Lee, Chang-Eon (Department of Cosmeceutical Science, Daegu Haany University)
Park, Gun-Hye (Department of Cosmeceutical Science, Daegu Haany University)
Kim, Han-Hyuk (Department of Cosmeceutical Science, Daegu Haany University)
An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
Publication Information
Journal of Applied Biological Chemistry / v.53, no.1, 2010 , pp. 13-20 More about this Journal
Abstract
Biological activities such as anti-oxidative and anti-microbial of the Seungmakalgeuntang, a traditional prescription, were evaluated. The electron donating ability of water, ethanol, supercritical fluid and 1,3-butylene glycol extract of Seungmakalgeuntang showed more than 50% at a 100 ppm concentration. At a 1000 ppm concentration, the superoxide dismutase-like activities of ethanol and supercritical fluid extract of Seungmakalgeuntang showed less than 50%. xanthine oxidase inhibition effect of the supercritical fluid extract showed more than 70% at a 1,000 ppm concentration, which was higher than vitamin C. From the measurement on lipid oxidation, the $Fe^{2+}$ chelating abilities of the supercritical fluid extract of Seungmakalgeuntang was more than 60% at a 100 ppm concentration. Also the $Cu^{2+}$ chelating abilities of supercritical fluid extract Seungmkalgeuntang was showed more than 60% at a 500 ppm concentration. Clear zones formed by sample against the human skin-resident microflora such as Staphylococcus epidermidis, Staphylococcus aureus and Propionibacterium acne of ethanol and supercritical fluid extract of Seungmakalgeuntang showed the highest among all the extracts tested using a 4mg/disc. The minimum inhibitory concentration (MIC) against both S. epidermidis and S. aureus showed 2,500 ppm in the extract of the supercritical fluid.
Keywords
anti-microbial; DPPH; lipid oxidation; seungmakalgeuntang; SOD; xanthin oxidase;
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Times Cited By KSCI : 16  (Citation Analysis)
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