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http://dx.doi.org/10.3839/jabc.2009.037

Antioxidant and Aldo-keto Reductase Family 1 B10 Inhibition Activities of Korean Local Plant Extracts  

Pan, Cheol-Ho (Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute)
Lee, Joo-Young (Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute)
Song, Dae-Geun (Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute)
Kim, Jong-Hwan (Specialty Crops Experiment Station, Gangwondo Agricultural Research and Extension Services)
Ahn, Soo-Young (Specialty Crops Experiment Station, Gangwondo Agricultural Research and Extension Services)
Bae, Deok-Sung (Department of Biology Education, College of Education, Chungbuk National University)
Kim, Young-Hoon (Department of Biology Education, College of Education, Chungbuk National University)
Lee, Jae-Kwon (Department of Biology Education, College of Education, Chungbuk National University)
Publication Information
Journal of Applied Biological Chemistry / v.52, no.4, 2009 , pp. 216-220 More about this Journal
Abstract
Aldo-keto reductase family 1 B10 (AKR1B10) has been considered as a potential cancer therapeutic target. Ethanol extracts prepared from 82 Korean local plants were examined for their antioxidant activity and inhibitory effects on recombinant human AKR1B10 (rhAKR1B10) in vitro. 21 extracts showed more than 80% of ABTS radical scavenging activity at $100\;{\mu}g/mL$ and 11 extracts inhibited more than 50% of rhAKR1B10 activity at $10\;{\mu}g/mL$. Especially, 9 extracts showed potent inhibition on rhAKR1B10 activity compared with positive control tetramethylene glutaric acid.
Keywords
ABTS radical scavenging activity; Aldo-keto reductase family 1 B10; aldose reductase-like 1; antioxidant; anti-cancer;
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