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http://dx.doi.org/10.3839/jabc.2008.047

Rat Lens Aldose Reductase inhibitory of Taraxacum mongolicum and two Cirsium species  

Jung, Mee-Jung (School of Biotechnology, Kangwon National University)
Heo, Seong-Il (School of Biotechnology, Kangwon National University)
Wang, Myeong-Hyeon (School of Biotechnology, Kangwon National University)
Publication Information
Journal of Applied Biological Chemistry / v.51, no.6, 2008 , pp. 302-306 More about this Journal
Abstract
To evaluated active principles for diabetic compolications from the Taraxacum mongolicum (T. mongolicum), Cirsium japonicum (C japonicum), and Cirsium setidens (C. setidens) and its constituents, as well as silymarin tested for their effect on rat lens aldose reductase. As a result, the MeOH extract of T. mongolicum ($IC_{50}\;8.71\;{\mu}g/mL$) have strong lens aldose reductase inhibition abilities. Also, Aldose reductase inhibitory showed an isolated luteolin ($IC_{50}\;20\;{\mu}M$) from the T. mongolicum and sliymarin ($IC_{50}\;13\;{\mu}M$).
Keywords
Aldose reductase; Cirsium japonicum; Cirsium setidens; Silymarin; Taraxacum mongolicum;
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Times Cited By KSCI : 5  (Citation Analysis)
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