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Suppressive Effects of Korean Indigenous Acanthopanax divaritacus on the Allergic Inflammation  

Park, Seul-Ki (Department of Medical Biotechnology, SoonChunHyang University)
Kim, Jum-Ji (Department of Medical Biotechnology, SoonChunHyang University)
Jeon, Yu-Mi (Department of Medical Biotechnology, SoonChunHyang University)
Lee, Mi-Young (Department of Medical Biotechnology, SoonChunHyang University)
Publication Information
Journal of Applied Biological Chemistry / v.50, no.3, 2007 , pp. 155-159 More about this Journal
Abstract
The water extracts of root, stem, and leaf from Korean indigenous Acanthopanax divaritacus were examined for their suppressive effects against allergic inflammations such as lipoxygenase activity, ${\beta}-hexosaminidase$ release, inflammatory cytokine production, and serum IgE level. The root extract inhibited the release of ${\beta}-hexosaminidase$, a degranulation marker, from rat basophilic leukemia cells (RBL-2H3) much more potently than the stem and leaf extracts. The root extract also significantly reduced the expression of $TNF-{\alpha}\;and\;IL-1{\beta}$ in the RBL-2H3 cells challenged with antigen. Moreover, there was a significant fall in the serum IgE level by the treatment of the root extract. Taken together, the root extract could be the most potent inhibitor of allergic inflammation, suppressing ${\beta}-hexosaminidase$ release and inflammatory cytokine expression, as well as reducing the rise of serum IgE level.
Keywords
Acanthopanax; anti-allergic inflammation; ${\beta}-hexosaminidase$; serum IgE;
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Times Cited By KSCI : 2  (Citation Analysis)
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