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Isolation of Flavonoids from the Fruits of Cornus kousa Burg  

Lee, Dae-Young (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Lyu, Ha-Na (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Kwak, Ho-Young (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Jung, La-Koon (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Lee, Youn-Hyung (Department of Horticultural Biotechnology, Kyung Hee University)
Kim, Dae-Keun (Department of Pharmacy, Woosuk University)
Chung, In-Sik (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Kim, Sung-Hoon (Graduate School of Oriental Medicine, Kyung Hee University)
Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
Publication Information
Journal of Applied Biological Chemistry / v.50, no.3, 2007 , pp. 144-147 More about this Journal
Abstract
Dried, unripe fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH and the concentrated extracts were partitioned between EtOAc and $H_2O$. From the EtOAc fraction, four flavonoids were isolated through repeated silica gel, ODS and Sephadex LH-20 column chromatographies followed by a preparative HPLC. Based on the spectroscopic data including NMR, MS and IR, the chemical structures of the compounds were determined as kaempferol (1), astragalin (2), hyperin (3) and isoquercitrin (4). These compounds were isolated for the first time from the fruits of this plant.
Keywords
Astragalin; Comus kousa; hyperin; isoquercitrin; kaempferol; NMR;
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Times Cited By KSCI : 4  (Citation Analysis)
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