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[ $\alpha$ ]-Glucosidase Inhibitors from the Roots of Codonopsis lanceolata Trautv  

Jung, Suk-Whan (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University)
Han, Ae-Jin (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University)
Hong, Hae-Jin (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University)
Choung, Myoung-Gun (Department of Pharmacognosy Material Development, Kangwon National University)
Kim, Kwan-Su (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University)
Park, Si-Hyung (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University)
Publication Information
Journal of Applied Biological Chemistry / v.49, no.4, 2006 , pp. 162-164 More about this Journal
Abstract
The roots of Codonopsis lanceolata afforded tangshenoside I(1) and $\beta$-adenosine (2) as $\alpha$-glucosidase inhibitors. Their structures were unambiguously determined by 1D and 2D NMR data including HMQC and HMBC experiments. Compounds 1 and 2 exhibited weak $\alpha$-glucosidase inhibitory activities in vitro with $IC_{50}$ of 1.4 and 9.3 mM, respectively.
Keywords
Codonopsis lanceolata; $\alpha$-glucosidase inhibitor; tangshenoside I; $\beta$-adenosine;
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