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Antioxidant Effects of Isoflavones from the Stem Bark of Cudrania tricuspidata  

Lee, Jin-Hwan (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University)
Lee, Byong-Won (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University)
Kim, Jin-Hyo (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University)
Seo, Woo-Duck (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University)
Jang, Ki-Chang (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University)
Park, Ki-Hun (Division of Applied Life Science (BK21 program), Institute of Agricultural & Life Sciences, Department of Agricultural Chemistry, Gyeongsang National University)
Publication Information
Journal of Applied Biological Chemistry / v.48, no.4, 2005 , pp. 193-197 More about this Journal
Abstract
Isoflavones 4'-O-methylalpinumisoflavone (1) and 5, 7, 4'-trihydroxy-6,8-diprenylisoflavone (2) were isolated from stem bark of Cudrania tricuspidata (Carr.) Bureau. These compounds were the first reported from this plant. Antioxidant activities 1 and 2 were evaluated by measuring their ability to scavenge DPPH and ABTS radicals. Diprenylisoflavone 2 showed strong scavenging activity against ABTS ($IC_{50}\;=\;16.3\;{\mu}M$), three-fold higher compared to genistein, which do not possess prenylated group which indicates strong scavenging activity against ABTS radical of isoflavone 2 was due to prenyl group.
Keywords
Cudrania tricuspidata; antioxidant; prenylated isoflavone; DPPH; ABTS;
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