[KSCI] Korea Science Citation Index Service

Prevention of Murine Acquired Immunodeficiency Syndrome (MAIDS) Development by Oriental Herb Extracts

Yang, Yun-Hee (Department of Genetic Engineering, Faculty of Life Sciences and Technology, Sungkyunkwan University)
Yang, Joo-Sung (Department of Genetic Engineering, Faculty of Life Sciences and Technology, Sungkyunkwan University)

Publication Information

Journal of Applied Biological Chemistry / v.48, no.4, 2005 , pp. 170-177 More about this Journal

Abstract

Oriental medicinal herb extracts (OHE) showing anticancer activities were investigated for effectiveness as antiviral drugs. Infection of MuLV to cell line resulted in formation of giant syncytia. Number of giant syncytia in culture treated with OHE decreased by 40% compared to that of non-OHE-treated cell culture. To determine OHE effects on progeny release, RT-PCR was performed. In vivo animal studies demonstrated effectiveness of OHE as antiviral drug when administered orally. After OHE administration, viral cytopathic effects decreased. Infected mice showed splenomegaly and over-proliferation of lymphocytes with decreased CD4+ cell counts. These symptoms decreased in OHE-treated mice, indicating OHE maybe useful therapeutics against MuLV/MAIDS as Human Immunodeficiency Virus (HIV)/AIDS animal model. Results show XC plaque assay and in vivo MAIDS model using MuLV are suitable tools for screening anti-retroviral drug candidates.

Keywords

Murine Leukemia Virus; Murine Acquired Immunodeficeincy Syndrome; Oriental herval extracts; Human Immunodeficiency Virus; AIDS;

Citations & Related Records

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