Browse > Article

Antibacterial, Free Radical Scavenging, and Proliferative Effects of Korean Fermented Soybean Paste (Doenjang) Extracts  

Yun, Soon-Il (Food Science & Technology Major, Division of Biotechnology, Chonbuk National University)
Publication Information
Journal of Applied Biological Chemistry / v.48, no.3, 2005 , pp. 138-143 More about this Journal
Abstract
Antibacterial, free radical scavenging, proliferative, and cytotoxicity effects of Doenjang extracts were examined. All samples except water extract showed strong antibacterial activity against oral bacteria, Streptococcus. pyogenes, S. mutants, S. sanguinis, S. sorbrinus, S. criceti, S. antinosus, S. gordonii, and Porphyromonas. gingivalis (MIC and MBC values: 0.08-1.25 and 0.16-2.50 mg/ml, respectively). DPPH method showed ethanol and ethyl acetate extracts are effective inhibitors of oral bacteria. Based on MTT assay, 24 h exposure to 0.31 mg/ml of all extracts, excepted water extract, resulted in strong cytotoxicity on KB cells. All extracts strongly inhibited human gingival fibroblast viability.
Keywords
fermented food; soybean paste; antimicrobial activity; radical-scavenging; cytotoxicity; gingival fibroblast;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Fungal microflora on Korean home-made meju /
[ Park, K.J.;Kim, Y.M.;Lee, B.M.;Lee, B.K. ] / Kor. J. Mycol.
2 Meju fermentation for a raw material of Korean traditional soy products /
[ Lee, S.S. ] / Kor. J. Mycol.
3 Effect of various fungi on the aflatoxin productivity in the culture of Aspergillus flavus /
[ Kim, E.F.;Chung, Y.;Kwon, S.P. ] / Kor. J. Prev. Med.
4 Antimutagenic effects of Doenjang (Korean fermented soypaste) and its active compounds /
[ Park, K.Y.;Jung, K.O.;Rhee, S.H.;Choi, Y.H. ] / Mutat. Res.   DOI
5 Degradation of aflatoxin during manufacturing of Doenjang and kanjang by traditional method /
[ Park, K.Y.;Lee, K.B. ] / J. Colle. Home Eco., Pusan Natl. Univ.
6 Effects of browning products and charcoal on the degradation of aflatoxin <TEX>$B_1$/<TEX> in Korean soysauce (kanjang) and its model system /
[ Park, K.Y.;Lee, E.S.;Moon, S.H.;Cheigh, H.S. ] / Kor. J. Food Sci. Technol.
7 Effect of ammonia and pH on the degradation of aflatoxin <TEX>$B_1$/<TEX> during the storage of Korean soysauce (kanjang) /
[ Park, K.Y.;Lee, E.S. ] / J. Korean Soc. Food Nutr.
8 Bowman-Birk soybean protease inhibitor as an anticarcinogen /
[ Yavelow, J.;Finlay, T.H.;Kennedy, A.R.;Troll, W. ] / Cancer Res.
9 Phytoestrogen genistein as an anti-staphylococcal agent /
[ Verdrengh, M.;Collins, L.V.;Bergin, P.;Tarkowski, A. ] / Microbes Infect.   DOI
10 Regulative actions of dietary soy isoflavone on biological antioxidative system and lipid metabolism in rats /
[ Kawakami, Y.;Tsurugasaki, W.;Yoshida, Y.;Igarashi, Y.;Nakamura, S.;Osada, K. ] / J. Agric. Food Chem.   DOI
11 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays /
[ Mosmann, T. ] / J. Immunol. Methods   DOI
12 Purification and characterization of subtilisin DJ-4 secreted by Bacillus sp. strain DJ-4 screened from doenjang /
[ Kim, S.H.;Choi, N.S. ] / Biosci. Biotechnol. Biochem.   DOI
13 Identification and antimicrobial activity of phenylacetic acid produced by Bacillus licheniformis isolated from fermented soybean, ChungkookJang /
[ Kim, Y.;Cho, J.Y.;Kuk, J.H.;Moon, J.H.;Cho, J.I.;Kim, Y.C.;Park, K.H. ] / Curr. Microbiol.   DOI
14 Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing the Bowman-Birk protease inhibitor /
[ Weed, H.G.;McGandy, R.B.;Kennedy, A.R. ] / Carcinogenesis   DOI
15 Structural requirements for differentiation-induction and growth-inhibition of mouse erythroleukemia cells by isoflavones /
[ Jing, Y.;Waxman, S. ] / Anticancer Res.
16 Isolation and identification of fibrinolytic bacteria from Korean traditional Chungkookjang /
[ Heo, S.;Lee, S.K.;Joo, H.K. ] / Agric. Chem. Biotech.
17 Purification and characterization of a fibrinolytic enzyme produced from Bacillus sp. strain CK11-4 screened from ChungkookJang /
[ Kim, W.K.;Choi, K.H.;Kim, Y.T.;Park, H.H.;Choi, J.Y.;Lee, Y.S.;Oh, H.I.;Kwon, I.B.;Lee, S.Y. ] / Appl. Environ. Microbiol.
18 Doenjang hexane fraction-induced G1 arrest is associated with the inhibition of pRB phosphorylation and induction of Cdk inhibitor p21 in human breast carcinoma MCF-7 cells /
[ Choi, Y.H.;Choi, B.T.;Lee, W.H.;Rhee, S.H.;Park, K.Y. ] / Oncol. Rep.
19 Antigenotoxic effects of water extract from Korean fermented soybean paste (Doenjang) /
[ Kim, J.G. ] / J. Food Prot.   DOI
20 His-His-Leu, an angiotensin I converting enzyme inhibitory peptide derived from Korean soybean paste, exerts antihypertensive activity in vivo /
[ Shin, Z.I.;Yu, R.;Park, S.A.;Chung, D.K.;Ahn, C.W.;Nam, H.S.;Kim, K.S.;Lee, H.J. ] / J. Agric. Food Chem.   DOI
21 Mutagenic and anti-mutagenic properties of meju and other Korean food products from fermented soybeans /
[ Rapp, N.S.;Chung, Y.;Shin, S.H.;Hong, I.S.;Jang, J.Y.;Seel, D.J. ] / Yonsei Med. J.
22 The antioxidant activity of genistein in vitro /
[ Record, I.R.;Dreosti, I.E.;McInerney, J.K. ] / J. Nutr. Biochem.   DOI
23 Reduction of aflatoxins by Korean soybean paste and its effect on cytotoxicity and reproductive toxicity-part 1. Inhibition of growth and aflatoxin production of Aspergillus parasiticus by Korean soybean paste (Doenjang) and identification of the active component /
[ Kim, J.G.;Lee, Y.W.;Kim, P.G.;Roh, W.S.;Shintani, H. ] / J. Food Prot.
24 Isoflavones found in Korean soybean paste as 3-Hydroxy-3-methylglutaryl coenzyme a reductase inhibitors /
[ Sung, J.H.;Choi, S.J.;Lee, S.W.;Park, K.H.;Moon, T.W. ] / Biosci. Biotechnol. Biochem.   DOI
25 Estrogenic activity of glycitein, a soy isoflavone /
[ Song, T.T.;Hendrich, S.;Murphy, P.A. ] / J. Agric. Food Chem.   DOI
26 Effects of soybean isofalvones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP /
[ Onozawa, M.;Fukuda, K.;Ohtani, M.;Akaza, H.;Sugimura, T.;Wakabayashi, K. ] / Jpn. J. Clin. Oncol.   DOI
27 Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells /
[ Di Virgilio, A.L.;Iwami, K.;Watjen, W.;Kahl, R.;Degen, G.H. ] / Toxicol Lett.
28 Suppression of the periodontophthic microflora in localized juvenile periodontitis by systemic tetracycline /
[ Slots, J.;Rosling, B.G. ] / J. Clin. Periodontol.   DOI
29 Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease /
[ Zambon, J.J.;Slots, J.;Genco, R.J. ] / Infect. Immun.
30 Antioxidant and antiproliferative activities of spimlina and chlorella water extracts /
[ Wu, L.C.;Ho, J.A.;Shieh, M.C.;Lu, I.W. ] / J. Agric. Food Chem.
31 Role of p38 in nitric oxide synthase and cyclooxygenase expression, and nitric oxide and <TEX>$PGE_2$</TEX> synthesis in human gingival fibroblasts stimulated with lipopolysaccharides /
[ Gutierrez-Venegas, G.;Maldonado-Frias, S.;Ontiveros-Granados, A.;Kawasaki-Cardenas, P. ] / Life Sci.   DOI