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http://dx.doi.org/10.3742/OPEM.2010.10.4.310

Anti-inflammatory and radical scavenging properties of Verbena officinalis  

Shim, Hwan-Ki (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Kim, Seong-Yeol (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Kim, Bo-Rim (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Cho, Jae-Park (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Park, Yae-Jeong (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Ji, Won-Geun (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Cha, Dong-Seok (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Jeon, Hoon (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Publication Information
Advances in Traditional Medicine / v.10, no.4, 2010 , pp. 310-318 More about this Journal
Abstract
Verbena officinalis (Verbenaceae) has been used as herbal medicine or health supplement in both Western and Eastern countries for centuries. In the present study, we examined the anti-inflammatory and antioxidant activities of the methylene chloride fraction of V. officinalis (VMC). To elucidate the anti-inflammatory properties of VMC, we investigated the inhibition effects of nitric oxide production in interferon-gamma (IFN-$\gamma$) and lipopolysaccharide-stimulated mouse peritoneal macrophages. VMC suppressed nitric oxide production, inducible nitric oxide synthase and cyclooxygenase-2 expression dose-dependently without notable cytotoxicity. In various radical scavenging assays, VMC exhibited strong scavenging effect on DPPH radical, superoxide radical, nitric oxide radical and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical. VMC also showed potent reducing power. These findings strongly suggest that VMC may be beneficial in oxidative stress-mediated inflammatory disorders.
Keywords
Verbena officinalis; Antioxidant; Anti-inflammatory;
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