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http://dx.doi.org/10.3742/OPEM.2010.10.2.051

Effects of Vitex rotundifolia on radical scavenging and nitric oxide production  

Choi, Jae-Ki (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Cha, Dong-Seok (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Lee, Yong-Jae (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Ko, Sung-Hoon (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Park, Ho-Jun (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Lee, Se-Yeoun (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Choi, Jae-Hyuk (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Jeon, Hoon (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
Publication Information
Advances in Traditional Medicine / v.10, no.2, 2010 , pp. 51-58 More about this Journal
Abstract
Vitex rotundifolia (V. rotundifolia) has been used for treating headache, dizziness, toothache and removal of fever as a traditional medicine in Korea. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of V. rotundifolia. In various radical scavenging assays, V. rotundifolia exhibited strong scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl free radical, superoxide radical, nitric oxide. To elucidate the anti-inflammatory properties of V. rotundifolia, we investigated the inhibition effects of nitric oxide production in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. V. rotundifolia suppressed nitric oxide production, iNOS and COX-2 expression dose-dependently through suppression of NF-$\hat{e}B$ activation without notable cytotoxicity. These findings mean that V. rotundifolia may be beneficial in oxidative stress-mediated inflammatory disorders.
Keywords
Vitex rotundifolia; Antioxidant; Anti-inflammatory;
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