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http://dx.doi.org/10.3742/OPEM.2010.10.1.001

A comparative study of radioprotection with Callophyllis japonica extract and amifostine against lethal whole body gamma irradiation in mice  

Shin, Tae-Kyun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Kim, Hee-Chul (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Kim, Jeong-Tae (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Ahn, Mee-Jung (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Moon, Chang-Jong (Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University)
Hyun, Jin-Won (Applied Radiological Science Research Institute, Jeju National University)
Jee, Young-Heun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Lee, Nam-Ho (Applied Radiological Science Research Institute, Jeju National University)
Park, Jae-Woo (Applied Radiological Science Research Institute, Jeju National University)
Publication Information
Advances in Traditional Medicine / v.10, no.1, 2010 , pp. 1-6 More about this Journal
Abstract
The efficacy of the radioprotective effect of Callophyllis japonica ethyl acetate (CJEA) extract was studied by comparing it to that of amifostine, a well-known radioprotective agent, and by evaluating the dose reduction factor, an indicator of radioprotective efficacy. Pretreatment with CJEA extract (100 mg/kg body weight) prior to receiving 12 Gy irradiation significantly improved the survival of jejunal crypts at 3.5 day post-irradiation, but attenuated the level of malondialdehyde compared to vehicle alone (P < 0.01). A similar gastroprotective effect was also obtained in the amifostine-treated irradiated group (P < 0.01). The efficacy of the radioprotective effect was further confirmed by the dose reduction factor, 1.41. Collectively, these results suggest that CJEA extract is a useful radioprotectant whose efficacy is similar to that of amifostine and whose radioprotective mechanism is in part the reduction of lipid peroxidation caused by gamma irradiation.
Keywords
Callophyllis japonica; Red seaweed; Jejunum; Radioprotection; Amifostine; Antioxidation;
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Times Cited By KSCI : 2  (Citation Analysis)
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